| Objective: To observe clinical effects of Ziyin Pinggan Qinayang decoction(affiliated hospital of liaoning university of traditional Chinese medicine professor ZHANG Ming-xue's empirical formula) for high-normal blood pressure and preliminarily discuss the concept and category of sub-health.Methods: Prospective, random contrast clinical study. We observed 200 patients with high-normal blood pressure belong to type of deficiency of YIN leading to hyper activity of YANG, these patients were divided randomly into treatment group (100 cases) and control group (100 cases), and respectively treated by Ziyin Pinggan Qinayang decoction and Qiju Dihuang Pill, and observe blood pressure levels, therapeutic effect of syndrome, blood lipids, blood glucose, etc of patients in the two group before and after treatment.Results: In treatment group the markedly effective rate of depressurization was 89% and the total effective rate was 95%, the markedly effective rate of symptom improving was 86% and the total effective rate was 95%; In control group the markedly effective rate of depressurization was 59% and the total effective rate was 80%, the markedly effective rate of symptom improving was 60% and the total effective rate was 75%; curative effectiveness in treatment group were superior to that in control group.Antihypertensive effect analysis, group comparison: systolic pressure and diastolic pressure have remarkable statistical significance (P<0.01), and treatment group was superior to control group. Intra-group comparison: Two groups before and after treatment have remarkable statistical significance, T test P<0.01. Covariance analysis of diastolic pressure: with the exception of diastolic blood pressure before treatment effecting on diastolic blood pressure after treatment, curative effect of two groups has difference, and treatment group was superior to control group. Antihypertensive effect Logistic regression analysis: drug was positively correlated with antihypertensive effect, therapeutic effect ascendancy of treatment group was 5.674 times that of control group, meanwhile, age and blood glucose were negative correlation with Antihypertensive effect.Therapeutic effect analysis of symptom of TCM, group comparison: except dim eyesight has not statistically significant (P>0.05), other 9 have remarkable statistical significance (P<0.01), and treatment group was superior to control group. Symptom integration Logistic regression analysis: drug of two groups were positively correlated with integration effect, therapeutic effect ascendancy of treatment group was 11.703 times that of control group, age, dim eyesight, tinnitus, texture of tongue, coated tongue, pulse tracings were negative correlation with Antihypertensive effect. Principal constituent and factor analysis of symptom integration of TCM: X1(vertigo), X4(five feverish centres), X8(texture of tongue)were mainly explained by F1(first common factor),that is principal syndrome of yin deficiency with yang hyperactivity and physical sign of tongue body, X5(dim eyesight),X10(pulse condition)were mainly explained by F2, that is malnutrition of eyes and physical sign of pulse condition, X2(headache), X3(waist soreness)were mainly explained by F3, that is malnutrition of oriffices on head and kidney, X6(Dry mouth)was mainly explained by F4, that is body fluid cannot flow upwards, X9(coated tongue)were mainly explained by F5, that is physical sign of tongue body, X7(tinnitus)were mainly explained by F6, that is malnutrition of ears, X1(vertigo), X4(five feverish centres), X8(tongue body)were main clinical diagnosis criterion for symptom of asthenic yin causing predominant yang. Clustering results from 10 symptoms show: before treatment, the patients with slight symptom of the two groups are mostly, but after treatment, healing patients in treatment group were more than that in control group. Curative effectiveness in treatment group were superior to that in control group.Therapeutic effect analysis of blood lipids and blood glucose, group comparison: after treatment, P value of blood lipids and blood glucose in control group and treatment group have remarkable statistical significance (P<0.01), and blood lipids treatment group was superior to control group, blood glucose control group was superior to treatment group.Multiple Regression and Correlation Analysis of blood pressure, blood lipids and blood glucose: analysis from Combination treatment group and control group, before treatment, systolic blood pressure, total cholesterol and high-density lipoproteins are related, in the case of other factors unchanging, increased of 1 unit of total cholesterol, systolic blood pressure increased by 0.313 units; increased of 1 unit of high-density lipoproteins, systolic blood pressure decreased by 0.134 units. Before treatment, diastolic blood pressure and total cholesterol are related, in the case of other factors constant, increased of 1 unit of total cholesterol, diastolic blood pressure increased by 0.181 units. Before treatment in treatment group, systolic blood pressure and blood glucose are related, in the case of other factors unchanging, increased of 1 unit of blood glucose, systolic blood pressure increased by 0.241 units. After treatment in treatment group, diastolic blood pressure, total cholesterol and blood glucose are related, in the case of other factors unchanging, increased of 1 unit of total cholesterol, diastolic blood pressure decreased by 0.237 units, increased of 1 unit of blood glucose, diastolic blood pressure increased by 0.225 units. Principal constituent and factor analysis of blood pressure, blood lipids and blood glucose: X1(systolic blood pressure), X2(diastolic blood pressure), X4(triglyeride), X5(low-density lipoprotein)were mainly explained by F1(first common factor),that is integrative risk factor of artherosclerosis, X3(total cholesterol)were mainly explained by F2(second common factor), that is risk factor of cholesterin, X6(alpha-lipoprotein) were mainly explained by F3(third common factor), that is risk counteract factor of artherosclerosis, X7(blood glucose) were mainly explained by F4(fourth common factor), that is factor of metabolism symptom-complex. Clustering results of blood pressure, blood lipids and blood glucose shows: before treatment, the lower of detection index in two groups are small, medium and higher are more, and after treatment, the lower of detection index in two groups were increased, higher were obviously decreased, but the mean values of three detection index in control group were superior to that in treatment group. Curative effectiveness in treatment group was superior to that in control group.Conclusion: Ziyin Pinggan Qinayang decoction is effective for high-normal blood pressure belong to type of deficiency of YIN leading to hyper activity of YANG, it not only lower blood pressure, improve symptom, but also lower blood lipids. Cardiovascular Sub-health is in the state between health and cardiovascular diseases. It is in cardiovascular diseases prophase state(change of symptoms, physical sign, physiological and pathology before getting sick), and possible to develop cardiovascular diseases, but currently,do not reach the diagnostic criteria of cardiovascular diseases, such as High-Normal Blood Pressure (hypertension prophase), blood lipids borderline rising, etc.
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