| Bio-industry is another leading industry on the rise after information technology. We have entered into a brand new bio-economic era. Our government first framed the "11th Five Plan"of bio-industry in 2007, which depicted the grand road for our bio-industry. On the general view, our bio-industry is just taking the first step. Compared with developed countries, there's a 5-year gap in the fundamental research, and a 15-year gap in industrialization. Therefore, studying the influencing factors and mechanism of realizing the industrialization of our bio-pharmaceutical industry will provide a theoretical guidance for our enterprises to adopt proper means in realizing industrialization, so that enterprises can lower the cost and shorten the time needed. In the meantime, it will provide theoretical support to our government in formulating industrialization-related policies. In all, it is very meaningful in shortening our gap with foreign biopharmaceutical industry and realizing our bio-industry target stated in the "11th Five Plan".Based on the current situation of our country's biopharmaceutical industry and focusing on the realization route, this thesis studies the influencing factors and mechanisms of realizing biopharmaceutical industrialization from the enterprises' view. This thesis is composed of 7 chapters. In Chapter 1, the background and significance of choosing this subject is elaborated, the question to be studied is raised, and the content & technological methods is briefly described. In Chapter 2, the current situation of the both domestic and overseas biopharmaceutical industry is summarized; the research development of influencing factors on industrialization is also summed up. Chapter 3 designs the scales of influencing factors, carries out empirical study and analyzes the results. Chapter 4 sums up the current research and development situation of industry cluster innovation network in both domestic and overseas. Group cases are used to reveal the promotion mechanism of industry cluster innovation network on the industrialization. How to use this mechanism to promote industrialization is also analyzed. Chapter 5 introduces the current research and development situation of capital factor. Group cases are used to analyze the promotion mechanism of government grant, venture investment, industry capital on the industrialization. Suggestions on 6 sources to enlarge industrialization capital are also made. Chapter 6 summarizes the current research and development situation of internal synergetic innovation. Group cases are used to analyze the promotion mechanism of technology and market, strategy, organization, system and culture on the industrialization. In Chapter 7, the conclusion of this thesis and an outlook on the future research orientation & content are proposed. Major research achievements are as follows:(1) Through case study, the following factors are found to have influence on the industrialization of our country's biopharmaceutical industry: laws and regulations, external cluster innovation network, capital, internal synergetic innovation, enterprises' R&D capability, operational team, guidance by leading companies, industry guidance from government, production facility and capability, sales network and capability. Among these factors, four of them are key influencing factors: laws and regulations, external cluster innovation network, capital and internal synergetic innovation.Through case study on internal synergetic factors, this thesis finds out that: resources assurance needs to be considered for biopharmaceutical companies to achieve synergetic innovation, while technology and market synergism is the most important synergetic factor in all the 3 phases of industrialization. Through case study on capital factor, this thesis finds out that: in pre-clinical stage, capital sources are mainly enterprises' own fund and government grant; in clinical stage, mainly enterprises' own fund, government grant, and venture investment; in marketing stage, mainly industry capital, enterprises' own fund and venture investment. The constitution of capital sources is very different with that of overseas.(2) Through group case study, the mechanism of cluster innovation network on biopharmaceutical industrialization is revealed: in pre-clinical stage, it's intellectual overflow, so it is most important for enterprises to cooperate with scientific research institutes during this stage; in clinical stage, the mechanism is centralized professionalism, it is most important for enterprises to cooperate with clinical CRO during this stage; in marketing & large scale sales stage, the mechanism is sales network-oriented, it is most important for enterprises to cooperation leading companies with great sales network during this stage. In the meantime, it is found out that the concentration of scientific research institutes doesn't have fully positive relation with biopharmaceutical industrialization.(3) Through group case study on the promotion mechanism of capital factor on biopharmaceutical industrialization, this article finds out that:①For government grant, its promotion mechanism is: capital + incubation effect. Government grant exerts notable promotion influence in both pre-clinical & clinical stages;②For venture investments, its promotion mechanism is: capital + appreciation effect of operation capability. Venture capital has evident promotion effect in all three stages of biopharmaceutical industrialization, especially in the pre-clinical R&D stages;③For industry capital, its promotion mechanism is:capital + network output effect. It has marked promotion effect in marketing & large scale sales stage. (4) On the premises that resources are guaranteed, the synergism of technology with other factors (including market, strategy, organization, system and culture) has the following promotion mechanism, as concluded through case studies:①The synergism of technology and other factors (including market, strategy, organization, system and culture) have important promotion mechanism on biopharmaceutical industrialization. Among them, the synergism of technology & market is the key synergetic factor.②In pre-clinical R&D stage, R&D dept. and marketing dept. co-promote the innovation strategic decisions by "information symmetry" mechanism; in clinical trial stage, the two departments enrich the product functions and perfect the usage methods by "information feedback" mechanism; in marketing & large scale sales stage, the two departments cooperate via "information penetration" mechanism, to provide basis for marketing dept. to formulate marketing strategies.③During the realization of industrialization, the synergism of technology and strategy is focus strategy with esteablishing intellectual protection system. Biopharmaceutical companies with different R&D capabilities can choose different strategic positioning, for example, leader in professional field, platform-based technology innovator, follower in professional field. All in all, the key method in technology & strategy synergism is protecting its intellectual property, no matter what strategy a biopharmaceutical company chooses.④The biopharmaceutical industrialization process has the feature of a "project". Organization forms based on project management thought will expediate the industrialization process.⑤Innovative culture with positive enterprising spirit will be the main stream culture of biopharmaceutical enterprises. And the motivational system for key innovation personnel is especially important for the technology and system synergism.
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