Fluorescent Sensored Binding And Assembly Behavior Of Cyclodextrin Derivaties

Supramolecular chemistry is a frontier research field and hotpot subject in current chemistry, where construction of functional supramolecular assembly mediated by cyclodextrin is one of the most impotant branches. In this text, the binding behavior between native a-cyclodextrin and model guest molecules either in aqueous or solid state were investigated in order to illustrate the driving forces during the assembly process. Moreover, chromatophore modified permethyl-β-cyclodextrins was synthesized and a 1D linear assembly was logically arrayed between this modified permethyl-β-cyclodextrins and sulphonated porphyrins, where FRET behavior was observed from chromatophore to prphyrin. Further, cyclodextrin was comprehensively used in biology due to its benign biocompatible and in this text several modified native cyclodextrin was synthesized and explored their usage in this field. The major contents of this thesis are as follows:1. The general aspect of supramolecular chemistry was described briefly, and the cyclodextrin chemistry, energy transfer systems based on cyclodextrin and new progress and important achievement on molecular recognition and assembly of cyclodextrin were reviewed respectively.2. BODIPY bridged permethyl-β-cyclodextrins was synthesized successfully via "click" chemistry and the formation of 1D supramolecular assembly between this host compound and water soluble porphyrin was intuitionistic constructed. The FRET behavior within this assembly was observed and the differences in energy transfer efficiency between the assembly and the 1:1 inclusion compound was elaborated by the method of computation and molecular simulation.3. The compelexation between native a-cyclodextrin and two azopyridine isomers were investigated either in aqueous solution or solid state, and the different driving forces during the process of host complexation with guest molecules were illustrated. Further, the trival differences among guest isomers will lead to the huge different packing mode of inclusion compound in solid state, guest molecules was partially released during the phase transfer from solution to solid. 4. Rohdamine derivative modified nativeβ-cyclodextrin was synthesized and organic compound driving this compound from ring-closed to ring-opened state was firstly discovered. Futher usage of this compound to sensor of amphatic amino acid was investigated.5. A gene vector was constructed by 2,6-pyridinedicaboxylic acid modified cyclodextrin, Tb(Ⅲ) and spermine modified admatane. The condensation of pDNA induced by this gene vector was investigated through several methods and its usage in biology was investigated for the first stage.