Biocompatibility Of Inorganic Porous Materials

Inorganic porous materials have attracted considerable research interests due to their wide applications in biocatalysis, biosensing, and bioseparation. In this thesis, inorganic porous materials including cerium -, yttrium -, silver-, iron-, nickel-, copper-, cobalt-, and zinc-oxide based porous materials were synthesized and in-situ deposited on microscope slides via a crystal colloidal tem plating methcd and the biocom patibility- of these inorganic porous materials, in particular inorganic porous oerium -based material, as cell culture scaffblds was evaluated using human gastric cancer cells (BGC -803) as model systan . By com paring the cell viability and migxation of BGC -803 cells cultured on the dish, the blank slide, and the inorganic porous ceriuum -basad materialdepositsd slide, it is revealed that some of inorganic porous m aterials show in proved adhesive ability, low toxiciy, and lelatively good bioocm patibilily for BGC -803 cells. In com parison with the cells cultured on the dish and the blank slide, the cells cultured the cells cultuied on inorganic porous material deposited slide show varied migration property and cell colonization in a small area, which m ay be due to their poious structure and inorganic skeleton. The study may help us further evaluate the feasibility of using inorganic porous materials as scaffolds/supports for modulating the cellular adhesion, proliferation, and m igration. Our results also indicated that the materials are biocom patible and suitable for potential tissue regeneration applications in bone reconstruction.