Microvascular End-to-side Anastomosis Using2-Octyl Cyanoacrylate

OBJECTIVE To assess the feasibility, safety and short term efficacy of end-to-side microvascular anatomosis using2-octyl cyanoacrylateMETHODS Forty Sprague Dawley rats were performed end-to-side anastomoses between carotid and external jugular vein. Twenty anastomoses were completed by adhesive and another twenty were completed by conventional suture technique as the control group. The rate of hemorrhage, time of surgery, burst pressure of anastomoses, patency rate, inner diameter of anastomoses and inflammatory cells count per HPF were compared between these two groups.RESULTS All40rats were alive1month after surgery. The rate of hemorrhage and burst pressure were similar between two groups. Anastomosing with adhesive spent less time. The anastomoses of adhesive group had higher patency rate and larger inner diameter1month after surgery. In histological observation, the inflammatory cell count of adhesive anastomoses is less than sutured ones.CONCLUSION The results of this study prove the feasibility, safety and benefit of2-octyl cyanoacrylate in end-to-side microvascular anatomosis. This is a potential technique to treat the diffuse coronary arterial disease.