The Expression Of FoxM1and EMT-associated Protein E-cadherin In Gastric Cancer And Its Clinical Significance

Background：Gastric cancer is one of the common gastrointestinal cancers, and is oneof the highest mortality cancers in China. At present, the mechanism of invasion andmetastasis of gastric cancer is still remain unclear. Epithelial-to-mesenchymal transition(EMT) is a physiologic process in which cells lose epithelial characteristics, such ascell-to-cell contact, and acquire mesenchymal morphological phenotype, such as increasedcell motility. Researches show that, as a EMT-associated protein, E-cadherin, whichmediates cell adhesion, is down-regulated or absent in many tumors and regarded as atumor metastasis suppressor gene. FoxM1, as a transcription factor, participates in andregulates the invasion and metastasis of tumors. However, research on FoxM1involved inregulating EMT and invasion and metastasis of gastric cancer is still rare, and remains tobe further studied and discussed.Objective：By detecting the expression of FoxM1and E-cadherin in gastric cancer, thecorrelation of FoxM1and E-cadherin will be analyzed to clear the clinical significance.Methods：Expression of FoxM1and E-cadherin in all70cases of primary gastric cancertissues and5cases of normal gastric mucosa were detected by immunohistochemistry S-P,and their correlation with characteristics of clinical materials were evaluated. The data wasstatistical analyzed by SPSS21.0.Results：1. In70cases of primary gastric cancer tissues, the number of the positive expression ofFoxM1is57, and the positive rate is81.43%, which is significantly higher than theexpression of the adjacent normal gastric mucosa(P<0.05). 2. The expression of FoxM1in gastric cancer with stage III/IV, grade III and lymph nodemetastasis or distant metastasis is significantly higher than the expression in gastric cancerwith stage I/II, grade I/II and no lymph node metastasis or distant metastasis(P<0.05).3. In70cases of primary gastric cancer tissues, the number of the positive expression ofE-cadherin is30, and the positive rate is42.86%, which is significantly lower than theexpression of the adjacent normal gastric mucosa(P<0.05).4. The expression of E-cadherin in gastric cancer with stage III/IV, grade III and lymphnode metastasis or distant metastasis is significantly lower than the expression in gastriccancer with stage I/II, grade I/II and no lymph node metastasis or distantmetastasis(P<0.05).5. In all70cases of primary gastric cancer tissues, there are36cases with positive FoxM1expression and negative E-cadherin expression. Meanwhile, there are9cases withnegative FoxM1expression and positive E-cadherin expression. The expression of FoxM1is negtive correlated with the expression of E-cadherin in gastric cancer(r=-0.255) and thedifference is significant(P<0.05).Conclusions：In gastric cancer, the increase of the expression of FoxM1and thedecrease or absence of the expression of E-cadherin are significantly associated with theTNM stage, the grade and lymph node metastasis or distant metastasis of gastric cancer.The expression of FoxM1is negatively correlated with the expression of E-cadherin ingastric cancer, suggesting that FoxM1may promotes the EMT of gastric cancer bydown-regulating the expression of E-cadherin, and thus participates in the progress ofEMT and invasion and metastasis of gastric cancer.