| Part I Association of serum lipoprotein ratios with insulin resistance in women with polycystic ovary syndromeObjective: To investigate the association between serum lipoprotein ratios and insulin resistance in women with polycystic ovary syndrome(PCOS).Methods: 105 PCOS patients and 109 age-matched healthy women were randomly enrolled in the study. The fasting glucose(FBG), fasting insulin(FINS), serum triglycerides(TG), total cholesterol(TC), high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) levels were checked, then TG/HDL-C ratio, TC/HDL-C ratio and LDL-C/HDL-C ratio were calculated. The homeostasis model assessment of insulin resistance(HOMA-IR) was used to calculate for insulin resistance.Results:HOMA-IR of PCOS patients was significantly higher than that of age-matched healthy women. Meantime, all lipoprotein ratios were significantly higher in PCOS patients as compared to healthy controls(P<0.05). TG/HDL-C ratio, TC/HDL-C ratio and LDL-C/HDL-C ratio were significantly correlated with HOMA-IR(P<0.05). The receiver operating characteristic(ROC) curve demonstrated that TC/HDL-C ratio had higher sensitivity and specificity in diagnosing PCOS with insulin resistance.Conclusion:This study demonstrates that serum lipoprotein ratios significantly correlates with insulin resistance and can be used as the markers of insulin resistance in PCOS patients.Part II Lipid accumulation product is related to metabolic syndrome in women with polycystic ovary syndromeObjective: Metabolic disturbances are common features of polycystic ovary syndrome(PCOS), which possibly enhance the risk of diabetes and cardiovascular disease. Lipid accumulation product(LAP) is an emerging cardiovascular risk factor. The aim of this study was to explore the ability of LAP to identify metabolic syndrome(MS) in PCOS women.Methods: In a cross-sectional study, anthropometric, biochemical and clinical parameters were measured in 105 PCOS women. Receiver operating characteristic(ROC) curve analysis was used to find out the cut-off points of LAP to predict MS. MS was categorized according to International Diabetes Federation(IDF) criteria.Results: The prevalence of MS was 43.8% in this study. PCOS women with MS had significantly higher LAP levels compared to those without MS. LAP was highly correlated with components of MS. ROC curve analysis showed that LAP was a significant discriminator for MS in PCOS women, and the optimal cutoff point of LAP to predict MS was 54.2(93.3% sensitivity, 96.7% specificity).Conclusion: LAP seems to be associated with MS and has a strong and reliable diagnostic accuracy for MS in PCOS women.Part III Association of serum vitamin D with depression in women with polycystic ovary syndromeObjective: To investigate the association of serum vitamin D with depression in women with polycystic ovary syndrome(PCOS).Methods: 210 PCOS patients were randomly enrolled in this study. A blood sample was obtained to test serum levels of 25-hydroxyvitamin D(25[OH]D). The depression in these patients was evaluated using the Beck Depression Inventory-II( BDI).Results: Of the 210 PCOS women, 76(36.2%) showed depression according to BDI scores. Serum 25[OH]D levels in PCOS women with depression were significantly lower than those in PCOS women without depression [11.6( 8.4–14.7) vs. 20.5(16.1–25.1)ng/ml, P< 0.05]. There was a significantly negative correlation between serum 25[OH]D levels and BDI scores(r =- 0.362, P< 0.05). Based on the receiver operating characteristic(ROC) curve, the optimal cutoff value for serum 25[OH]D level as an indicator for predicting depression in PCOS women was estimated to be 11.5 ng/ml, with an area under the curve of 0.908. Serum 25[OH]D levels were independently associated with depression in Logistic analysis.Conclusion: Our study demonstrated that lower serum 25[OH]D levels were associated with depression in PCOS women. Vitamin D supplementation may provide new proposal for the treatment of depression in women with PCOS. |
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