| Currently the percutaneous implant failure rate is still a problem, its main reason is that the implant high modulus of elasticity and easy to bacterial infections, etc., how can you make the percutaneous implant both lower modulus of elasticity and have stronger antibacterial ability has always been a diligent direction of the researchers.Laser solid forming technology of titanium powder cladding can be in porous titanium implant surface coating, sharply reduce on the surface of the implant surface elastic modulus.If you can add a thermal stability in titanium powder raw material good antibacterial powder, together with the cladding on the implant surface to form porous antibacterial coating, then can significantly raise the successful rate of to percutaneous planting.Nanometer zinc oxide thermal stability, antibacterial ability and good biocompatibility.This topic in titanium powder mixed with nano zinc oxide powder as raw material, using a laser three-dimensional molding in antibacterial coating on the titanium substrate surface preparation of porous materials is discussed antibacterial powder adding proportion, scan rate, the influence law of offset distance on the coating performance;Under optimized process conditions, the composite nano zinc oxide was prepared on the surface of pure titanium titanium porous antibacterial coating;And on the physical and chemical properties of the coating, antibacterial and biocompatibility through the evaluation, explore a new method of the preparation of pure titanium surface porous antibacterial coating, for application of the next step in percutaneous planting field experimental basis.Methods:1. By grouping design, preparation, coating forming using scanning electron microscopy(seem), energy spectrum analysis technology and mechanics experiment, the analysis of the raw material powder antibacterial agent adding proportion, scanning rate, distance to coating, macro, porosity, and the influence law of coating bonding strength.2. Under optimized conditions, the surface of pure titanium was prepared porous titanium compound nanometer zinc oxide antibacterial coating, surface treatment and screening of clinical commonly used sand coarsening method and of specimen prepared by micro-arc oxidation, polishing of pure titanium as the control group, using scanning electron microscopy, energy spectrum analysis and contact Angle measurement technology evaluation of the four groups of surface physical properties.3. The compression test method is adopted, titanium composite stress-strain curve of nanometer zinc oxide porous antibacterial coating, the elastic modulus were studied.4. Using scanning electron microscopy and porosity test technology of titanium composite nano zinc oxide porous three stereoscopic structure of antimicrobial coating were studied.5. By s. aurous bacteria cultivation technology research with material coating material related antibacterial performance.6. The osteoblast culture techniques with material coating material and osteogenesis related biological performance.Results:1. Add nano zinc oxide powder in titanium powder raw material, using laser solid forming technology in the preparation of porous pure titanium surface antimicrobial coating method is practical, the quality of nanometer zinc oxide ratio of 10 ﹪ when the preparation containing zinc coating and the coating quality is better.2. When the scan rate of 4.5 mm/s, coating porosity and the best high strength combined with titanium substrate.3. When the scan rate of 4.5 mm/s, the offset distance of 1200 microns coating and titanium substrate bonding strength, the highest reached 51.70 ± 3.72 MPa.4. The preparation o f porous titanium compound nanometer zinc oxide antibacterial coating optimization of process parameters, namely the nano zinc oxide added mass than 10﹪, scan rate of 4.5 mm/s, the offset distance of 1200 microns; Under the optimized parameters of the preparation of the porous antibacterial coating; Rules for comparing porous structure of the coating, the aperture size is about 450 microns, the coating has good connectivity, and detected in coating on the surface of zinc.5. The coating under the microscope show three-dimensional porous structure, pore interconnection, the main elements for oxygen, titanium, zinc, the micro-arc oxidation is obviously better than the invasive group and sandblasting coarsening.6. obtain the stress strain curve of the coating, the coating of the modulus of elasticity, its value is 16.6 GPa, consistent with human bone tissue elastic modulus.7. Coating can be prepared into any thickness, its positive average aperture is 450 microns, pore rate of 42.6 ﹪;Its side of the average pore diameter is 300 microns, pore rate was 36.8 ﹪.8. The coating of the antibacterial rate above 98% within 14 d, and almost no attenuation; Porous titanium coating and micro-arc oxidation coating and pure no antibacterial effect, the rough surface for adhesion and proliferation of Sa.9. The coating can promote osteoblast adhesion, proliferation and ALP activity of osteoblasts in the direction of the coating surface more stereoscopic stretching. |
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