Study Of Complex Brain Functional Networks Under Magnetic Stimulation At Acupoint Based On EEG

Acupoint is the breakthrough point between body surface stimulation and internalnervous system regulation. Magnetic stimulation technique is expected to become a newacupoint therapy because of many incomparable advantages, but the curative effect ofmagnetic stimulation on acupoint is lack of unified and rational evaluation methods, whichneeds to be further explored. The rapid development of human connectome and complexnetwork theory provides a new way to the research of magnetic stimulation efficacy onacupuncture point.The brain functional network construction and analysis of magnetic stimulation onNeigaun (PC6) is carried out based on the high temporal resolution electroencephalogramusing complex network method. It aims at exploring the influence of magnetic stimulationon the brain functional connection from a holistic point of view, and providing new ideas tothe efficacy evaluation of acupoint magnetic stimulation especially in psychiatric diseasesrehabilitation treatment. The main contents were as follows:1. The EEG acquisition experiments of magnetic stimulation on acupoint andnon-acupoint with different frequencies were designed and carried out. The associatedfeatures of the acquired EEG data with high resolution were analyzed usingcross-correlation and mutual information method. The results found that brain functionalconnectivity obviously enhanced under high frequency magnetic stimulation on Neiguanacupoint.2. The unweighted and weighted brain fuctional networks were constructed based onthe multi-channel EEG associated features of magnetic stimulation on, acupoint and thenetwork characteristics were further analysed. The results found that the edges, averagedegree, average clustering coefficient and global efficiency of brain functional networksobservably increased, however, the average path length decreased under high frequencymagnetic stimulation on Neiguan acupoint. The characteristics change caused bynon-acupoint stimulation was significantly less than the acupoint stimulation.3. The centrality and centralized degree were analysed of the unweighted andweighted brain fuctional networks. The results found that the degree centrality and closecentrality obviously increased of nodes in frontal lobe, central region, and the parietal lobe,however, the betweenness centrality decreased in the parietal lobe and central region underhigh frequency magnetic stimulation on Neiguan acupoint. The centrality change caused by non-acupoint stimulation was significantly less than the acupoint stimulation.4. The small world properties of the brain functional networks were also evaluated inthis paper. The results found that all brain functional networks had small world propertiesin different magnetic stimulation stages of all subjects, and the small world propertiessignificantly enhanced under high frequency magnetic stimulation on Neiguan acupoint.The small world properties change caused by non-acupoint stimulation was less than theacupoint stimulation.