Study On Diagnosis And Treatment Regularity Of Gasp Syndrome Based On Ancient Medical Records Date

Objective:In the study, in order to offer more reference and new ideas for the clinical treatment of Gasp Syndrome, we probed the diagnosis and treatment regularity through collecting the ancient medical documents of Gasp Syndrome and researching the medical case of Gasp Syndrome selected from the ancient documents by modern computer technology and statistical analysis.Methods:①We reviewed and summarized the understanding of the ancient Chinese Doctor on Gasp Syndrome from through collecting the ancient medical documents of Gasp Syndrome and using literature study methods.②We selected the ancient medical cases of Gasp Syndrome from the ancient medical documents and normalized the data of the cases to establish the database of the general information, etiology, disease location, pathogenesis, prescription, medicines and symptoms. Then we analyzed the database using the methods of mathematical statistics and data mining, such as frequency analysis, factor,an.alysis, clustering analysis,canonical correlation analysis and association rules analysis via statistical software SASV9.1. We mined the potential relationship of symptoms-symptoms, medicines-medicines, symptoms-medicines, disease location-medicines and pathogenesis-medicines to summarize and generalized the understanding and the diagnosis and treatment regularity of the Gasp Syndrome.Results:In the cases with gender and age record,52.42%of the patients were men, and61.58%of the patients were middle-aged and aged people. The etiologies of85.28%of the cases were pathological products, exogenous factors, dietary factor, over-work and over-rest factor, and emotional factors. The etiology of10.35%of the cases was the therapeutic error factor. The disease location of84.50%of the cases were lung, spleen and kidney.45.70%of the cases were affected by two organs at the same time. The pathogenesis of the49.42%of the cases was intermingled deficiency and excess. The pathogenesis of37.30%of the cases was water, dampness, phlegm and fluid. The pathogenesis of54.30%of the cases was Qi deficiency, Yang deficiency and Yin deficiency. Then we analyzed the database of the symptoms and medicines using the methods of frequency analysis, factor analysis, clustering analysis, canonical correlation analysis and association rules analysis and got63common symptoms,6symptom factors,16symptom clusters,11groups with two symptoms,60common medicines,7medicine factors,13medicine clusters,37groups with two medicines,45groups with three medicines,36groups with four medicines and seven pairs of canonical correlation variables.Conclusions:①Gasp Syndrome is possibly common in middle-aged and aged people and male patients are more than female patients.②The main etiologies of the Gasp Syndrome are pathological products, exogenous factors, dietary factor, over-work and over-rest factors and emotional factors. And the therapeutic error factor can not be ignored.③The Gasp Syndrome is the syndrome of deficiency in origin and excess in superficiality, and its main pathogenesis is deficiency syndrome accompanied with excess syndrome.④Five organs and six fu can lead to the Gasp Syndrome, and the closest organs are lung, spleen, and kidney. Two related organs leading to the Gasp Syndrome are very common.⑤There are17types of the Gasp Syndrome, including superficies cold and interior heat, intense lung heat, turbid phlegm obstructing lung and so on.⑥We can use17medicine types including qi-invigorating drugs, expectorant cough suppressant and anti-asthmatic drugs and so on,37common medicine pairs including ginseng+liquorice, atractylodes ovata+ginseng, astragalus membranaceus+ginseng and so on,15groups of three medicines including ginseng+liquorice+atractylodes ovata, tangerine peel+ginseng+liquorice and so on,9groups of four medicines including tangerine peel+ginseng+liquorice+atractylodes ovata, poria cocos+ginseng+atractylodes ovata+liquorice and so on, and15prescriptions including kidney-qi-tonifying pill, buzhong yiqi decoction and so on to treat the Gasp Syndrome. ⑦There is a great significance to research the ancient books of TCM using the modern computer technology and statistical analysis.