Synthesis Of Organoboron And Application Of Coenzyme NADH Model In Photoreaction

The photocatalytic organic reaction has become a hotspot in chemical research, in which photocatalysts play a key role. The traditional metal photocatalyst has a wide range of application,good catalytic effect, but high toxicity, difficult to recovery and rare metals are expensive.Therefore, the development of organic photocatalyst has become the focus of domestic and foreign scientists. Coenzyme NADH have the potential of photocatalyst with high oxidation potential and reduction potential respectively, which can be excited under the Irradiation of light to get or give the electron. This project intends to use the photocatalytic method to study the organic reaction between two or more molecules with coenzyme.In this paper, we introduce the research progress of NADH model, mainly used as a reducing agent in organic reaction. In recent years, the international research on NAD+ model as a photocatalyst has attracted attention. As a reduction state of NAD+, NADH model as a photocatalyst will become a hot topic of the next study of the international community. Our current focus is to find the appropriate substrate to accept the NADH model given under the light of the electrons, and we found two examples: one is the diazonium salt, the other is the high price of iodonium salt. Especially the high price of iodonium salts, which have attracted much attention.We also introduced the use of high-priced iodonium salts in organic synthesis in recent years. It is desirable to select the appropriate high-priced iodonium salt for the NADH model as a catalyst for the photoreaction. We also introduce the progress of C(sp3)-CF3 research and the progress of the synthesis of quinoline derivatives.We found that the high purity iodonium salt of trifluoromethyl can be obtained by the electrons provided by NADH, get trifluoromethyl free radicals involved organic reaction. We optimized the conditions of the reaction and expanded the substrate. We have demonstrated in experiments that diazonium salts can be obtained as phenyl radicals. In the presence of acetonitrile and olefins or alkanes, quinoline derivatives were obtained. We optimized the reaction and substrate development, and finally studied the application of this reaction in drug synthesis.We also study the synthesis of organic borides. Organic boride is a useful organic matter that has a wide range of uses in organic synthesis. We first introduce the research progress of synthetic organic borides. Although there are many reports on the synthesis of organic borides, but these methods still have many shortcomings, such as the need for ligands and strong base. We do not need to use any ligand and base through the nano-catalyst to achieve the synthesis of organic boride in very mild conditions and the functional group compatibility is very good. We have also used the nano-metal catalyst for characterization.