The Correlation Between Cunkou Pluse Diagnosis With Abi And Apoe Of Non-dipper Essential Hypertension

Pulse diagnosis is an important clinical practice of traditional Chinese medicine,modern Chinese medicine are only "Cunkou pluse diagnosis" as a clinical pulse diagnosis technology.The first time in history,"Cunkou pluse diagnosis" of the diagnosis is derived from "Nan Jing".Cunkou pluse diagnosis can reflect the law of blood circulation,but also the starting point of the pulse flow through.Non-dipper hypertensive refers to the night blood pressure higher than normal,circadian curve lighter or disappearance of a class of high blood pressure,and arteriosclerosis,cardiovascular and cerebrovascular events are closely related.Cunkou pluse for the radial artery of some segments,is an important part of traditional Chinese medicine syndrome system,and arteriosclerosis and hypertension have a correlation.In this study,we investigated the relationship between serum ApoE gene polymorphism and peripheral arterial ankle brachial index(ABI)and intramedullary pulse in non-dipper hypertensive patients.This study is divided into two parts:literature research and clinical research.Clinical research,including three content,one non-dipper type of hypertension and pulse correlation study,the second is non-dipper hypertensive patients wrist index and pulse correlation study And the relationship between ApoE gene polymorphism and pulse pattern in non-dipper hypertensive patients.The first part of the literature review:This part has carried on the literature review and the discussion from three aspects.The literature 1 is the origin and the theory of the pulse diagnosis,and introduces the development of history,history and important position.Literature 2 is a non-dipper type of hypertension research,introduced the non-dipper type of hypertension and the characteristics of traditional Chinese medicine treatment.Literature 3 is a study of ApoE gene polymorphism,and the study of ApoE gene polymorphism,hypertension and TCM view are introduced.The second part is the literature research.This part of the intangible pulse "alone take the mouth" of the development context and historical evolution of the literature."Achieve","Beijing","Beijing" Medical Bookstore will be difficult to understand the theory and text into other medical books,and the correction of the "hard" was elected to the Song Dynasty Hospital doctor qualification examination of the designated materials.Since then,the "Nan Jing"access to the mouth of the mouth alone to become the main diagnostic method of the four yuan.Ming and Qing dynasties so far the whole of nearly a thousand years of medical thought are deeply "Nan Jing" effect,Cunkou pluse diagnosis become the basic content of the traditional Chinese medicine.The third is the clinical research:Part 1 Study on the correlation between non-dipper type hypertension and pulseThe DS01-C pulse collection device was used to analyze the characteristics of nocturnal hypertrophy in patients with non-frosted hypertensive patients.For the Chinese Academy of Traditional Chinese Medicine Xiyuan Hospital from January 1,2015 to January 31,2016,124 cases of non-scalded hypertensive patients.The DS01-C type objective pulse diagnosis instrument was used to collect the pulse,and the blood pressure data were collected by the 24-hour ambulatory blood pressure monitoring device in the dynamic blood pressure chamber of Xiyuan Hospital.A total of 124 patients were included in the non-scaly hypertensive patients,including 61 males(49%)and 63 females(51%).27(22%)were younger than 60 years old,73(58%)from 60 to 80,and 24(or 19%)over 80 years of age.Mean blood pressure was controlled at systolic blood pressure of 145.7 � 23 and diastolic blood pressure of 86.1 � 13.6.The rate of decline in blood pressure at night was statistically significant(P<0.05).The correlation coefficient of the knot is 0.26(P = 0.03).The correlation coefficient of the generation pulse is 0.286(P = 0.01).The correlation coefficient of the pulse is 0.193(P=0.32).The results suggest that when the night blood pressure drop more,then the knot,generation,sliding three pulse frequency increases.Part 2 Study on the correlation between ankle-brachial index(ABI)and the pulse diagnosis in non-dipper hypertensive patientsThe arterial blood pressure was measured by the DS01-C pulse acquisition device and the Omron arteriosclerosis tester.The correlation between the pulse and the ankle index was analyzed.On the Chinese Academy of Traditional Chinese Medicine Xiyuan Hospital from January 1,2015 to January 31,2017,124 cases of non-dipper hypertensive patients with Dao Sheng DS01-C-type objective pulse diagnosis device to collect the pulse;Omron arteriosclerosis analyzer simultaneous monitoring of physical examination Personnel ankle brachial index,heart rate,mean arterial pressure,while recording height,weight,age,gender.A total of 124 patients were included in the trial.Ankle brachial index and pulse with statistically significant(P<0.05)are generation,real,floating,chord,slippery.The correlation coefficient of the generation pulse is 0.294(P=0.01).The correlation coefficient of real pulse is 0.318(P = 0.00).The correlation coefficient of floating veins is 0.191(P = 0.33).The correlation coefficient of the pulse is 0.743(P = 0.00).The correlation coefficient of the pulse is 0.287(P =0.01).Ankle brachial index and nocturnal blood pressure decline rate was not statistically significant(P>0.05).Part 3 Relationship between ApoE gene polymorphism and pulse pattern in non-dipper hypertensive patientsApplication of DS01-C pulse acquisition equipment,objective analysis of non-scaly hypertensive patients with pulse.To investigate the association between ApoE gene polymorphism and pulse pattern in non-scalded hypertensive patients.A total of 124 patients with non-dipper hypertensive patients were enrolled in this study.The patients were collected from the Chinese Academy of Traditional Chinese Medicine,Xiyuan Hospital,January 1,2015,January 31,2017.(Apolipoprotein E3/E3),112TT+ 158TT(Apolipoprotein E2/E3/E3)in the whole blood samples were detected by the method of detection of E(ApoE)genotyping kit(gene chip method)(Apolipoprotein E3/E4 type),112TT + 158T/C type(apolipoprotein E2/E3 type),112T +(Apo E2;ApoE3;Apo E4)were divided into three groups:112T/C + 158T/C(apolipoprotein E2/E4)Apo E2 contains apolipoprotein E2/E2 type and apolipoprotein E2/E3 type;Apo E3 contains apolipoprotein E2/E4 type and apolipoprotein E3/E3 type;Apo E4 contains apolipoprotein E3/E4 type Lipoprotein E4/E4 type.Results ApoE and pulse were statistically significant(P<0.05).The correlation coefficient of the veins was 0.205(P = 0.23).In general,the pulse of Chinese medicine has unique scientific value.In this study,non-scaly hypertensive patients were used as subjects to study the characteristics of anu of oral hypertension and the ankle brachial index and ApoE gene polymorphism Preliminary discussion.There are also shortcomings in this paper,such as less sample size,pulse classification is relatively simple,with a view to further enhance the work in the future.