Photothermal Effect Based Biomimetic Nanomaterials For Disease Therapy

In some recent years,biomimetic photothermal nanomaterials bring out the huge potential in disease treatment.In this dissertation,three different biomimetic nanomaterials have been designed,they have high photo-thermal conversion efficiency and good biocompatibility.Furthermore,the biomimetic nanomaterials designed in this dissertation have been employed in disease treatment base the phototermal effect of them.Following is the brief introduction.1.A hyaluronic acid(HA)encapsulated copper sulfide(HA-CuS)nanoparticles with excellent biocompatibility and remarkable photothermal translation efficacy is synthesized for transdermal drug delivery.By simply controlling the NIR laser irradiation power and time,it enable controllable the thermal ablation effect that the stratum corneum almost disappeared in certain areas and without damage of deeper skin tissue.The above mode of transdermal drug delivery enable the model biomacromolecule of bovine serum albumin into skin in vivo.Furthermore,the feasibility of the HA-CuS-mediated transdermal insulin delivery for type 1 diabetes therapy of nude mice is investigated.It presents sustained and efficient transdermal insulin delivery to decrease the blood glucose level for longer time than insulin injection,providing great potential for clinical application.2.Fuse membrane materials derived from red blood cells(RBCs)and melanoma cells(B16F10 cells)to create a hybrid biomimetic coating(RBC-B16),and RBC-B16 hybrid membrane camouflaged doxorubicin(DOX)-loaded hollow copper sulfide nanoparticles(DCuS@[RBC-B16]NPs)are fabricated for combination therapy of melanoma.The DCuS@[RBC-B16]NPs are comprehensively characterized,showing the inherent properties of the both source cells.The experiment results show that the DCuS@[RBC-B16]NPs exhibit highly specific self-recognition to source cell line in vitro,and achieve markedly prolonged circulation lifetime and enhanced homogenous targeting abilities in vivo inherited from the source cells.Thus,the DOX-loaded[RBC-B16]-coated CuS NP platform exhibits excellent synergistic photothermal/chemotherapy with about 100%melanoma tumor growth inhibition rate.The reported strategy may contribute to personalized nanomedicine of various tumors by combining the RBCs with liomotypic cancer membrane accordingly on the surface of nanoparticle.3.Fuse bacterial outer membrane vesicles(OMVs)and melanoma cells membrane to create a hybrid biomimetic coating(OMV-CC)and OMV-CC hybrid membrane camouflaged polydopamine nanoparticles(HPDA@[OMV-CC]NPs)are fabricated for combination therapy of melanoma.The experiment results show that the HPDA@[OMV-CC]NPs exhibit highly specific self-recognition to source cell line in vitro which derived from B16F10 cell membrane and excellent photothermal therapy efficiency which derived from polydopamine nanoparticlcs.Futhermore,HPDA@[OMV-CC]NPs display high dendritic cell activation efficacy in vivo which resulting from OMVs,and HPDA@[OMV-CC]NPs may induce long-term antitumor immune responses.Introduce the OMVs into biomimetic nanomaterials will likely supply a new method for treat various cancers.