Synthesis Of Copper Sulfide Nanoparticles For The Applications In Drug Delivery And Photothermal Therapy

Copper sulfide nanocrystals have received more and more interests due to their size-and shape-dependent physical and chemical properties.These materials,have enormous potential for applications in future low-cost solution-processed photovoltaic,microelectronic,and optoelectronic devices.Copper sulfide nanocrystals also could be used in biomedicine,such as biosensor,molecular imaging,photothermal therapy,due to their strong absorbance in near infrared range(NIR).Scientists proposed that NIR absorbance observed in cation-deficient Cu2xS nanocomposites originates from the localized surface plasmon resonance(LSPR)of free holes in the valence band.We could obtain the desired characteristic absorbance by change stoichiometries.As a novel photothermal conversion agent,copper sulfide nanocrystals possess many advantages over gold nanorods(Au NRs),for instance,low-cost,smaller size,broader absorbance which could easily match with specific lasers,The most important thing is that they have a higher photothermal conversion efficiency.Aimed at the practical applications of copper sulfide nanocrystals in cancer therapy,this dissertation focuses on the design and preparation of nano-size CuS-based drug carriers.Copper sulfide nanocrystals were synthesized and assembled into multifunctional nanocomposites as drug carrier for the photothermal therapy and chemotherapy.The main research results are summarized briefly as follows.(1)A facile one-pot method was presented for the preparation of colloidal stable,monodispersed,highly PEGylated CuS@mSiO2-PEG nanocomposites in sub-50 nm size.The as-prepared material exhibited good photothermal efficacy and pH-responsive drug release behavior,which makes it excellent vehicle for the combination of photothermal and chemotherapy.Since mSiO2-based nanocomposites are heavily explored recently,this synthetic method may provide a standard approach for the preparation of colloidal stable,highly PEGylated mesoporous silica nanocomposites for biomedical applications.(2)The preparation of colloidal stable,monodispersed CuS@Polymer-CD-RGD nanocomposites about 20 nm size by high temperature thermolysis.The as-prepared material exhibited outstand extinction coefficient in the NIR range and high photothermal efficacy,which makes it excellent candidate for photothermal therapy.Meanwhile,anticancer drug DOX can also be loaded on the nanoparticles for chemotheropy..