Research On The Synthesis And Medical Imaging Theranostic Application Of Nanobiomaterials

In recent years,nanobiomaterials have attracted a great deal of attention due to their excellent medical imaging and therapy.Theyare used extensivelyinmedical imaging and therapy.Synthesis of excellent nanobiomaterials with simple and quick methods has attracted considerable attention.In area of medical imaging,PET/CT examination is expensive.The penetrating ability of fluorescence imaging and photoacoustic tomography is low.Therefore,we decided to use CT imaging and MR imaging for medical imaging of nanobiomaterials.In the area of tumor treatment,because of radiation exposure by radiation therapy,we used phototherapy for tumor treatment.PEG-WO3-x,Fe3O4@Mn O2-PAA,Co-P-PEG were synthesized and characterized.In the first chapter,the synthesismethod,surface modification methods,and current advances of nanobiomaterials are introduced in detail.In the second chapter,we synthesized highly water-soluble Fe3O4@Mn O2-PAA nanoparticles through a simple and green microwave-assisted hydrothermal method.The nanoparticles showed core-shell structure.The core of Fe3O4 exhibited enhanced MR T2 image,and the shell of Mn O2 exhibited enhanced MR T1 imaging when existingin tumor tissue because of the Mn2+.MR T2 imaging of the Fe3O4@Mn O2-PAA nanoparticles provided the anatomical information,and the p H response MR T1 imaging could improve the diagnosis of tumor.Furthermore,Fe3O4@Mn O2-PAA nanoparticles exhibited excellent absorption in near infrared region,and could be used for phototherapy.The p H-responsive dual-model MR-guided tumor eradication by photothermal therapy provided new idea for theranostic in transition-metal based nanobiomaterials.In the third chapter,the PEG-WO3-x was synthesized via a fast and facile high-temperature solvothermal method with PEG as the surfactant.Compared to clinical iodinated(53)contrast of CT imaging,this nanoparticle(W 74)exhibited excellent CT imaging.Besides CT imaging within tumor and blood circle,we applied PEG-WO3-x for digestive tract CT imaging first time,the postpross with 3 D imaging showed counter of stomach.Furthermore,PEG-WO3-x nanoparticles exhibited excellent absorption in near infrared region,and could be used for phototherapy.PEG-WO3-x could be used for CT-guided tumour eradication by photothermal therapy.In the fourth chapter,we synthesized highly water-soluble Co-P-PEG nanoparticles through high-temperature solvothermal method.The nanoparticles exhibited excellent uniform morphology and dispersion,low cytotoxicity and tissue toxicity.Co-P-PEG showed excellent MR T2 imaging both within tumor and blood circle.Furthermore,Co-P-PEG nanoparticles exhibited excellent absorption in near infrared region,and could be used for MR-guided phototherapy.In the fifth chapter,the monodisperse and water-soluble PEI-Ba Gd F5 were synthesized via an environmentally friendly,fast and facile microwave-assisted method.The PEI-Ba Gd F5 nanoparticles exhibited features with spherical,smooth surface and uniform distribution.The diameter of particle size is about 30 nm,with low cytotoxicity and tissue toxicity.The PEI-Ba Gd F5 nanoparticles exhibited excellent CT imaging and MR T1 imaging.24 hours after intravenous injection of nanoparticles,the liver exhibited excellent CT imaging and MR T1 imaging,which indicated the ability of targeted hepatic imaging with dual-model MR and CT imaging.The last chapter is asummary ofthe synthesis,surface modification methods,medical imaging and tumor treatment with nanobiomaterials.