Preparation Of Functional Element-doped Mesoporous Silica/Composite And Its Application In Tissue Damage Repair

Compared with the mesoporous bioglass,the mesoporous silica nanoparticle possesses the controllable size and structure.However,the structure of silica is stable and bioactivity is poor.Based on the biological functional elements,doping biological ions into the mesoporous silica is a good method to construct the bioactive mesoporous nano-materials.According to the requirement of dental caries repair and skin damage repair,doping the different functional ions and loading the different drug into the mesoporous silica,designing the novel multifunctional bioactive nano-mesoporous materials and exploring the biological effect between the element and element,element and drug,and element,element and drug,provide the potential multifunctional tissue repair materials for dental caries repair and skin regeneration.Three parts of the main contents and results in this study are described as follow:1.Design of the Ca doped mesoporous silica with the activity to induce the apatite-mineralization by doping Ca ion into mesoporous silica nanoparticle(MCS).Loading the Ciprofloxacin hydrochloride(CiH)into mesoporous channel endowed the MSC with antibacterial property.Different from the inorganic fillers with enhanced mechanical property reported in the previous study,as biological inorganic nanofillers,MCS-CiH not only improved the mechanical property,but also endowed the resin composite with antibacterial property and apatite-mineralization.In addition,when the resin composites were worn,the process of the deposition of the apatite minerals were accelerated,which suggested the resin composite could smartly to the wear and reduce the possibility of the dental caries failure due to the marginal leakage and the bacterial infection.2.Doping the Zn element into mesoporous silica changed the structure from the solid structure to the hollow structure.Besides,the loading the CiH into the mesoporous channel enlarged the hollow structure.As the biological nano-materials,the Zn doped hollow mesoporous silica(HMZS)/polycaprolactone nano-composite wound dressing were prepared by the electrospun method.The releasing Si ion from the nano-composite wound dressing could promote the proliferation and migration of endothelial cells and fibroblast and accelerate the wound healing;the releasing Zn ion and drug CiH both in low concentration achieved the synergetic antibacterial effect;the releasing Zn ion could promote the hair follicle regeneration and the antibiotic CiH accompany by the Zn ion releasing from the nano-composite membrane enhanced the hair follicle regeneration,which provides a novel the wound dressing for the bacterial infected skin wound healing.3.Except for the single the antibacterial element Zn,the Fe element with angiogenic and antibacterial effect were future introduced into the mesoporous silica to prepare the Fe doped mesoporous silica(MFS).The mesoporous channel and the complexation of Fe ion enhanced the loading of Curcumin(Cur)with antibacterial effect,angiogenic effect and scar inhibition,and the Cur loaded MFS(MFSC)were obtained.The polycaprolactone and gelatin as the biocompatible polymer,the MFSC/polymer(MFSCP)nano-composite bioactive wound dressing was obtained by the electrospun method.The bioactive nano-composite membrane possessed the photothermal effect and could inhibit the bacterial growth by the photothermal effect,and the released Fe ion and Cur.The released Si ion,Fe ion and Cur from the nano-composite membrane promoted the proliferation of the endothelial cells,accelerated the wound healing and promote the deposition of collagen and ordered arrangement,thus causing the scar inhibition in chronic wound healing.This multifunctional wound dressing provides a choice for chronic wound healing including the scar inhibition.Based on the above study and corresponding results,the introduction of functional element and drug not only regulated the structure of mesoporous nano-materials,but also endowed the nano mesoporous materials with versatility.Moreover,the method is universal.For the repair of different tissue with different requirement,doping the corresponding biological functional element and active drug could construct the multifunctional bioactive materials with potential tissue repair.