| ObjectMental Retardationhas become an important social problem,with its obvious negative effects on the mental and physical health for children.However,no significant treatment in western medicine has been found.In clinc,we found that Jinsanzhen has great effect on mental retardation.In order to further improve the status of the Jinsanzhen in the treatment of mental retardation in children,this study used more scientific and rigorous clinical research and mathematical statistics methods to carry out a multi-center clinical randomized controlled study to observe the effect of Jinsansanzhen on mental retardation in children.Clinical efficacy and safety,as well as an objective evaluation of efficacy,provide scientific basis for the promotion and application of Jinsansanzhen therapy.MethodsThis subject enrolled patients,from December 2015 to December 2017,in the Provincial Key Specialties Guangzhou Yuexiu Children's Hospital Children's Encephalopathy Treatment Center,First Affiliated Hospital of Guangzhou University of Chinese Medicine Acupuncture and Moxibustion Clinic and Guangdong Provincial Maternal and Child Health Hospital Guangdong Mentally Handicapped Children Treatment Center.In the end,316 cases of children with mental retardation met the inclusion criteria were randomly divided into Jin Three Needle group?n=209?and the regular group?n=107?.In the treatment group,acupuncture treatment of three-pronged acupuncture treatment was performed on cases.In detail,the main acupoint includes Sishenzhen,Naosanzhen,Zhisanzhen,Niesanzhen,and the acupuncture treatment was performed 6 times a week,lasting for 4 months,an interval of 2 weeks and another 4 months.As control,in the control group,oral brain rehabilitationwas performed on others(40mg/kg·d-1).Frequency of the treatment was kept the same as the treatment group,4 months a course of treatment,observed 2 courses.Before and after treatment,nimodipine scoring was used to evaluate the clinical efficacy of the primary clinical symptoms,intelligence quotient?FIQ?,and social adaptive behavior quotient?ADQ?before and after treatment in all subjects.Inappropriate IQ?FIQ?and socially adaptive behavioral quotient?ADQ?cannot be assessed due to age,language barrier,incomprehension,etc.Therefore,efficacy evaluation was based only on the improvement of ten major clinical manifestations?poor memory,poor calculation power,poor comprehension,poor response,speech impairment,limb weakness,hand-foot disorder,runny nose,restlessness,and limb twitching?.A total of 33 subjects?age>6 years old who can basically understand the problems raised by the doctor and can basically express their own ideas?were selected for the treatment group and the control group.IQQ?FIQ?and social adaptive behavior quotient?ADQ?were selected.Observe and analyze the data before and after treatment.Finally,a database was established andthe results were analyzed by use of SPSS 20.0software package.ResultIn the treatment group,203 cases completed with 6 cases of loss;in the control group,97 cases completed with 10 cases of loss.The average age of cases was 6.25±3.41year in the treatment group?150boys,53girls?,and 6.49±3.79year?77boys,20girls?in the control group,separately.The distribution of syndrome in the treatment group includes 96 cases of kindney and liver yin deficiency,58 cases of heart and spleen deficiency,57 cases of phlegm and blood stasis and 22 cases of blood stasis due to qi deficiency.The control group includes 40 cases of kindney and liver yin deficiency,26cases of heart and spleen deficiency,19 cases of phlegm and blood stasis and12 cases of blood stasis due to qi deficiency.Before the treatment,no significant difference was found between the treatment group and the control group,in poor memory and poor calculation;meanwhile,significant differences were found in poor comprehension,poor response and poor language ability.The conditions of poor comprehension,poor response and poor language ability in the Jinsanzhen group were worse than the regular control group.The total curative effect of the treatment group and the control group after 1 course of treatment and 2 courses of treatment were compared,and there was significant difference between the two groups?P<0.05?.Since the effects of different centers may have different effects on the total curative effect,the curative effect levels are reclassified into two grades.Both effective and effective merging index are defined as the effective index,and the invalidity index is still invalid index.A stratified analysis of the efficacy in each center is conducted.The relative efficacy of treatment compared with the control group,the relative risk?RR?was 0.099,0.286 and 0.278,respectively.The consistency test of the RRs of the three centers?Breslow-Day test?x2=2.546,P=0.280.Therefore,the central effect is not obvious,and the efficacy data of the three centers can be combined for analysis.This analysis showed that this trial was not affected by the difference in efficacy of multicenter treatment.The efficacy of the treatment group was better than that of the control group both after the first course of treatment and after the second course of treatment.There was significant mental retardation?MR?in the children treated with Jinsanzhen therapy?P<0.05?.The comparison between the treatment group and the control group for one course of treatment and the improvement of the condition after two courses of treatment showed that there was a significant difference in the symptoms of poor memory,poor comprehension,and poor response in the 1 course and 2 courses of treatment?P<0.05?.No significant difference between poor ability and poor language ability?P>0.05?.This analysis showed that the treatment group had better symptoms of poor memory,poor comprehension,and poor response than the control group.The third group improved the main clinical symptoms,especially the poor memory,poor understanding and poor response.The improvement of intelligence quotient?FIQ?and social adaptive behavior quotient?ADQ?is not only related to the treatment method,but also related to pre-treatment conditions,age,and other factors.Therefore,the IQ of the 33 subjects in the treatment group and the control group?FIQ?and social adaptive behavioral quotient?ADQ?were used for 1 course of treatment and 2 courses of treatment were analyzed with covariance.After adjusting for FIQ,ADQ,and age before treatment,the course of treatment,the improvement of IQ after two courses of treatment?FIQ?and the number of social adaptive behavior quotients?ADQ?were still significant difference.This analysis shows that the treatment group IQ?FIQ?and social adaptive behavior quotient?ADQ?improvement is superior to the control group both after the first course of treatment and after the second course of treatment.The Jinsanzhen therapy improves IQ and improves children's adaptability.Behavioral disorders.ConclusionsBased on the above clinical data,it can be concluded that the Jinsanzhen to treat children with mental retardation can improve the children's poor memory,poor understanding,reaction and other symptoms,improve IQ and improve children's adaptive behavior disorders,and convenient economy,Significant effect,safety?Reliable,worthy of further clinical use. |
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