APOE Polymorphisms In Connection With The Susceptibility To Osteoporotic Fracture

Objective:APOE gene regulates bone metabolism via directly or indirectly methods.This study was designed to discuss the correlation of apolipoprotein E(APOE)polymorphisms with the susceptibility to osteoporotic fracture,as well as the effects of APOE polymorphisms for bone mineral density(BMD)level in osteoporotic fracture patients.Methods:BMD levels of 50 osteoporotic fracture patients and 51 healthy people were detected by dual energy X-ray absorptiometry(DEXA)of American LUNAR company.APOE genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism(PCR-RELP)method.Association between APOE polymorphisms and osteoporotic fracture susceptibility was represented by odds ratios(ORs)with 95%confidence intervals(95%CIs).Results:The BMD values of different body parts of the patients were apparently lower than those of the healthy people(P<0,05).The E4 allele of the APOE gene was more frequently discovered in cases than in controls,which indicated that APOE E4 allele was significantly associated with increased susceptibility for osteoporotic fracture(OR=3.357,95%CI=1.25-8.99).E4 allele carriers had significantly lower BMDs at the Ward’s triangle and lumbar L2-L4 segment than non-E4 allele carriers(P<0.05).Conclusions:APOE may be correlated with osteoporotic fracture.When compared with no APOE E4 allele carriers,APOE E4 allele carriers had significantly higher susceptibility for osteoporotic fracture approximately about 3.357 times.The E4 allele of the APOEgene may cause a higher likelihood of fracture at Ward’s triangle and lumbar L2-L4 segment via reduce the BMD of them,and may be a significant marker for osteoporotic fracture.