Impact Of Main Vessel Calcification On Procedural And Clinical Outcomes Of Bifurcation Lesion Undergoing Provisional Single-stenting Intervention:a Multicenter,Prospective,observational Study

Background:Both bifurcation and calcified coronary lesions pose challenges for percutaneous coronary interventions(PCI)and are associated with poor procedural and long-term outcomes.However,few data on the combined effects of bifurcation and calcification on coronary artery disease(CAD)patients undergoing PCI are availableObjective:This study evaluated the impact of main vessel(MV)calcification on the procedural and long-term outcomes in patients with CAD who underwent provisional single stent PCI.Methods:This is a multicenter,prospective,observational study.Patients with bifurcation lesions were enrolled at 10 PCI centers in China from January 2015 to December 2017.Intravascular ultrasound(IVUS)or optical coherence tomography(OCT)were performed in all patients to evaluate the MV calcification.Patients were treated with provisional single stent strategy using drug eluting stents(DES)and followed-up at 1 month,6 month and 12 months after discharge by telephone contact or outpatient visit.Repeated coronary angiography was performed within 1 year.We compared the procedural success rates in MV and in side-branch(SB),and target lesion failure(TLF),defined as a composite of cardiac death,non-fatal myocardial infarction(MI),definite or possible in-stent thrombosis(ST)and target lesion revascularization(TLR)between patients with and without MV calcificationResults:A total of 185 subjects were enrolled according to the inclusion and exclusion criteria of this study.MV calcification was detected in 119(64.3%,calcification group)and not found in 66(35.7%,non-calcification group)patients.The angiographic success rate of MV was 95.8%in the calcification group and 97.0%in the non-calcification group(p=0.91);the angiographic success rate of SB was 32.8%in the calcification group and 53.0%in the non-calcification group(p<0.05).During the one-year follow-up period,recurrent angina were significantly increased in calcification group than non-calcification group(17.65%vs.6.06%,p<0.05).Target lesion failure(TLF)occurred in 14(11.8%)patients in the calcification group and in 13(19.7%)in the non-calcification group(p=0.31).Multivariate regression analysis showed the same result(hazard ratio[HR]1.23,95%confidence interval[CI]:0.76-1.52,P=0.47).Conclusions In patients with coronary bifurcation lesion treated with provisional one stent approach,calcification of MV is associated with lower SB procedural success rate and increased recurrent angina;however,it was not associated with an increased risk of TLF.Clinical Trial Number:ChiCTR-OOC-17012831.