Study Of ABUS In The Diagnosis Of Breast Tumors And Usefulness Of Real-time CEUS Guided Coaxial Needle Biopsy For Focal Liver Lesions

Purpose:This study aimed to compare the diagnostic efficacy of automated breast ultrasonography(ABUS),handheld ultrasonography(HHUS),mammography(MG)and magnetic resonance imaging(MRI)in detecting breast cancer.Materials and Methods:This study was a prospective study.From January 2016 to March 2017,375 eligible female subjects aged 30-69 were enrolled,all of whom underwent ABUS and HHUS examinations.Among them,236 subjects underwent MG examination and 127 subjects underwent breast MRI examination.A total of 158 cases underwent biopsy and confirmed 55 cases of breast cancer.The final diagnosis of the disease was the gold standard,and the diagnostic efficacy of ABUS,HHUS,MG,MRI for breast cancer was analyzed,and the difference was compared by Z test.Subgroup analysis was performed based on differences breast density.Results:ABUS,HHUS,MG,MRI showed high diagnostic efficacy in different groups,and their diagnostic efficacy were not significantly different(P>0.05).However,the area under curve(ROC)(0.968 v.s.0.929),sensitivity(0.981 v.s.0.927),specificity(0.953 v.s.0.930),positive likelihood ratio(21.323 v.s.13.426),negative likelihood ratio(0.019 v.s.781),positive predictive value(0.627 v.s.0.515)and negative predictive value(0.998 v.s.0.993)of ABUS were superior to HHUS.In addition,in dense breasts,the AUC(0.958 v.s.0.878),sensitivity(0.960 v.s.0.800),positive likelihood ratio(22.285 v.s.18.571),negative likelihood ratio(0.041 v.s 0.209),positive predictive value(0.631 v.s.0.588)and the negative predictive value(0.996 v.s.0.984)of ABUS were superior to MG.Conclusion:In the diagnosis of breast cancer,ABUS has good and similar diagnostic efficacy with HHUS,MG and MRI.However,ABUS clinical diagnostic value may be more desirable than HHUS.In addition,in dense breasts,the diagnostic value of ABUS may be superior to MG.Objective:To evaluate the consistency of automated breast ultrasonography(ABUS),handheld ultrasonography(HHUS),mammography(MG)and magnetic resonance Imaging(MRI)in the diagnosis of breast lesions by BI-RADS.Materials and Methods:This study was a prospective study.From January 2016 to March 2017,a total of 375 subjects were included in the study.All subjects underwent ABUS and HHUS examinations,236 subjects underwent MG examination,127 subjects underwent breast MRI,and 158 cases underwent pathological examination.The results of these four imaging examinations were recorded in the BI-RADS classification.The consistency between these four imaging examinations was compared by Kendall's tau-b.The consistency of ABUS with pathological results was compared by Kappa consistency test.Results:In the diagnosis of breast lesions,ABUS was highly consistent with HHUS or pathological results(Tau-b=0.790;A=0.615).There were 2 cases of ductal carcinoma in situ,ABUS was evaluated as BI-RADS4,and HHUS was evaluated in BI-RADS3.There were 5 cases of breast cancer,ABUS was evaluated as BI-RADS4,and MG was evaluated as BI-RADS 1 or 3.Taking the pathological results as the gold standard,the diagnostic sensitivity of ABUS was 0.981(95%CI:0.890-0.999),the specificity was 0.708(95%CI:0.609-0.791),and the area under curve(AUC)was 0.845(95%CI:0.785-0.906).Conclusion:ABUS was highly consistent with HHUS in the diagnosis of breast lesions.In some intraductal lesions,ABUS was superior to HHUS.In addition,in some non-calcified lesions in dense breasts,ABUS or HHUS can make up for the deficiencies of MG diagnosisPurpose:This study analyzed the differences and diagnostic value of imaging characterization of benign and malignant breast tumors in automated breast ultrasonography(ABUS).Materials and Methods:This study was a prospective study.From January 2016 to March 2017,a total of 155 eligible cases with pathology were included.Among them,100 cases of benign breast tumors and 55 cases of breast malignant tumors.The difference in imaging characterization of benign and malignant breast tumors was analyzed by T test or chi-square test.This study also analyzed diagnostic value of the main imaging characterization and ABUS.Result:Tumor shape,orientation,margin,echo pattern,posterior features,calcification,architectural distortion,and retraction phenomenon are important for distinguishing between benign and malignant tumors.The margin of the tumor has the highest diagnostic value for breast malignant tumors.Its area under curve(AUC),sensitivity,specificity,positive predictive value and negative predictive value were 0.873(95%CI:0.814-0.932),0.945(95%CI:0.839-0.958),0.800(95%CI:0.705-0.870),0.722(95%CI:0.602-0.818)and 0.963(95%CI:0.890-0.990),respectively.The AUC,sensitivity,specificity,positive predictive value,and negative predictive value of ABUS for the diagnosis of breast malignant tumors were 0.836(95%CI:0.773-0.899),0.981(95%CI:0.890-0.999),0.690(95%CI:0.588-0.776),0.635(95%CI:0.523-0.734)and 0.985(95%CI:0.912-0.999),respectively.Conclusion:There are significant differences in imaging characterization between benign and malignant breast tumors.In the ABUS examination,the tumor margin is the most diagnostic value for distinguishing between benign and malignant tumors.ABUS has a good diagnostic ability for breast malignant tumors.Purpose:To evaluate the utility of real-time contrast-enhanced ultrasound(CEUS)guided coaxial needle biopsies for focal liver lesions(FLL)that were inconspicuous or could not be accurately identified the active site on B-mode ultrasound(US).Materials and methods:This prospective study included 76 patients who had CEUS-guided coaxial needle biopsies for FLL between December 2015 and June 2017.We recorded characteristics of target lesions.We evaluated conspicuity of target lesions and accuracy of identifying the active site of target lesions on B-mode US and CEUS using a 5-point scale.Patients were divided into three groups,and analyzed according to body mass index(BMI).Based on the final diagnosis,the diagnostic performance was evaluated.Results:The mean size and depth of target lesions were 41.5±28.5 mm and 47.9±18.9 mm on CEUS,respectively.In arterial phase,the enhanced pattern of target lesions varied.The conspicuity of target lesions and accuracy of identifying the active site of target lesions was significantly improved on CEUS compared to B-mode US(p<0.05).The three BMI groups had significant differences in conspicuity of target lesions after using CEUS(p<0.05).The high BMI group had a greater change in conspicuity of lesions compared to the normal BMI group or the low BMI group(p<0.05).The sensitivity,specificity,and accuracy of this technique for the diagnosis of FLL were 0.928,1.00 and 0.934,respectively.Conclusion:Real-time CEUS-guided coaxial needle biopsy can be very useful for FLL that are inconspicuous or cannot be accurately identified the active site on B-mode US.