Studies On Multi-channel Closed-loop Stimulation System And Its Application In Rat’s Temporal Lobe Epilespsy

Epilepsy is one of the most popular neural diseases,about one-third of these patients could not benefit from anti-epilepsy drugs or surgery.Neuro-modulation has proven remarkably safe and effective in the treatment of many neural diseases.Recently,closed-loop stimulation is been increasingly applied to treat medical refractory epilepsy.Since the mechanism of closed-loop stimulation is still unclear,there are still many challenges in the treatment of epilepsy with closed-loop stimulation.For example,how to design the closed-loop stimulation system for implantable applications with both high performance and low power,how to choose the best stimulation pattern with optimal stimulation sites and stimulation parameters,how to design the closed-loop algorithm to guarantee the reliability of stimulation,and meet the requirement of long-term online seizure detection with low power.To solve these problems,this thesis did following researches:Firstly,this thesis developed a compact and high-performance multi-channel closed-loop stimulation system,which was able to implement long-term continuous closed-loop stimulation experiments.Compared with commercial approaches,this system has advantages in low cost,low complexity,high performances,and high flexibility.Secondly,this thesis proposed a novel multi-site closed-loop stimulation for treatment in refractory epilepsy,implemented this method in multi-channel closed-loop systems and applied on rats with acute epilepsy,then analyzed the efficacy of multi-site closed-loop stimulation on different kinds of seizures,and discussed the mechanisms underlying the suppression of seizure onset and propagationThirdly,this thesis proposed a novel energy-efficient cascade seizure detection algorithm.This approach improved the high-performance machine learning methods with low-power architecture.It was successfully implemented in a multi-channel closed-loop system and was demonstrated from long-term online detection on rats with chronic epilepsy.In conclusion,the preliminary results of this thesis are significant to the clinical treatment of refractory epilepsy with the closed-loop system and offer valuable references and guidance to the design and application of implantable closed-loop systems.