The Dynamic Changes Of The Microbiome On The Skin Surface Of Diabetic

The number of colonized microorganisms in the human body is nearly 10 times that of the host cells,and the number of genes is more than 100 times.The organism's colonized microorganisms are involved in the metabolism of amino acids and heterologous organisms,as well as vitamins,isoprenoids,and other nutrients.Synthesis.The microbial flora diversity and structural changes in the body will lead to abnormal metabolism of the body and cause metabolic diseases such as obesity and diabetes.Will affect the healing process of the wound,but it is unclear exactly what this effect is.In this study,we used 16S rDNA high-throughput detection to understand the structural differences in the microbial flora of the feet in normal patients and patients with diabetes at different stages of the disease.The results show that the microbial flora and the abundance of bacterial flora in patients with diabetes and the structure of microbial flora in healthy volunteers are significantly different from those of patients with diabetes.At the same time,the microbial flora of patients with the same disease cycle The structures have obvious similarities.Then we performed KEGG pathway and COG(orthologous protein cluster)analysis to understand that during the course of diabetes,certain changes in the physiological function of the microbial flora occurred.COG analysis was first used to group functionally related genes to understand the functions of related genes,and then KEGG transmission was analyzed to understand the microbial flora involved and possibly involved in the metabolic pathways of the body.The results showed that the gene function of patients with diabetes was significantly different from that of normal volunteers.After the illness,the microbial flora structure and gene function of the patients with diabetes who had suffered from chronic diseases were relatively more serious.Close to normal.This study has not shown that human ovarian mesenchymal stem cell secretion(HFS)can effectively promote wound healing,and there are fewer secretions,rapid crusting,and small scars during wound healing.The results show that HFS can promote the continuous and uniform secretion of VEGF,recruit CD68 cells,inhibit the secretion of IL-6 and CRP,promote the process of wound vascularization,and ease the metabolic response.Macrophages may be involved in the decline of antibiotics and vascularization.Helps transform wounds into normal tissue.The paper also carried out research on wound healing and microbial flora changes.This study found that during the process of wound healing,the microbial flora showed a dynamic change trend.The bacterial structure variation and abundance of diabetic rats were significantly higher than those of normal rats..During the wound healing process of diabetic rats,the microbial flora showed a trend of first decrease and then increase.And at the same time,the microbial flora structure of diabetic rat hair in the same healing stage is more similar.Analysis of the relative abundance of samples between groups revealed a similar trend in the distribution of skin microbial flora in stepwise clinical experiments,that is,normal mice have significant potential strains,and the abundance ratio is large,occupying an absolute advantage.When the blood glucose changes in mice,the proportion of bacteria that originally accounted for a large proportion decreased,while the proportion of bacteria that accounted for a small proportion increased.Using the tips of wounds,the bacterial flora and the occurrence,development and healing of diabetes-related wounds Enough correlation.