| Background Chronic Obstructive Pulmonary Disease(COPD)is a common,preventable and treatable disease,it is characterized by persistent respiratory symptoms and airflou limitation,that is due to airway and /or alveolar abnormalities usually caused by significant exposure to noxious particles or gases.Chronic Obstructive Pulmonary Disease(COPD)is a major cause of chronic morbidity and mortality throughout the world,it is the third leading cause of death in the world according to the World Health Organization WHO,and the first leading cause of death of the respiratory disease,represents an important public health challenge,and Become a major public health problem.COPD can be divided into stable stage and acute exacerbation stage(acute exacerbation of COPD,AECOPD)in clinic,AECOPD is the main cause of repeated hospitalization in patients with COPD,and is also an independent risk factor for death in patients with COPD,leading to a serious decline in lung function,overall muscle strength,activity endurance and health-related quality of life(HRQOL).It seriously endangers people’s health and becomes a heavy burden on people’s health resources.There are two main therapeutic approaches for COPD currently: pharmacotherapies and nonpharmacologic treatment.Pulmonary rehabilitation(PR)has been explicitly proposed by the GOLD as the first-line nonpharmacologic for COPD.Pulmonary rehabilitation is a comprehensive intervention based on thorough patient assessment followed by patient-tailored therapies,which include exercise training,education and self-management intervention,but are not limited to these,designed to improve the physical and psychological condition of people with chronic respiratory disease,and promote the long-term adherence to health-enhancing behaviors.aiming at behavior change.It is agreed that pulmonary rehabilitation(PR)is applicable to the COPD stable stage patients,but at present,the research of pulmonary rehabilitation in patients with acute exacerbation of COPD(AECOPD)is still relatively less,Whether can run pulmonary rehabilitation early in AECOPD,and how to do pulmonary rehabilitation,there are still some controversy,the current research with high level evidence is limited,and there evaluation method has a bigger difference.The main purpose of pulmonary rehabilitation in AECOPD is to reduce the symptoms of dyspnea,clearing the airway,promote expectoration,improve exercise capacity and oxygenation index,reduce the disability caused by disease.The feasibility and effect of pulmonary rehabilitation on AECOPD has been accepted preliminary.but when and how to do it to make sure the safety of the patient,and maximize the benefits,there is still no standards.This research aims to discuss the efficacy and safety of this pulmonary rehabilitation exercise in hospitalized patients with AECOPD.In order to provide more clinical evidence,to promote the further development of pulmonary rehabilitation.Object 1.Measure and compare the difference of chronic obstructive pulmonary disease Assessment Test(CAT)、Modified Medical Research Council(m MRC)、six-minute walk test(6MWT)、Borg scale score(Borg)and lung function between AECOPD patients with pulmonary rehabilitation treatment group and conventional treatment group when they are on admission and discharge,then to analyse the clinical efficacy and safety in hospitalized patients with AECOPD.2.Measure and compare the difference of the average days of hospitalization between AECOPD patients with pulmonary rehabilitation treatment group and conventional treatment group when they are on admission and discharge,then to analyse the clinical efficacy and safety in hospitalized patients with AECOPD.Methods 1.Collecting the clinical data of all patients,including gender,age,GOLD stage and lun function.2.Pulmonary rehabilitation group: complete all scales and lung function testing on admission,according to the guidelines,using basic treatment,including respiratory support,oxygen,drug treatment such as anti-infection,expectorant and anti-inflammatory,besides,pulmonary rehabilitation is added at the the second day after admission and continued until discharged,pulmonary rehabilitation is completed and supervised by the medical staff,then complete all scales and lung function testing when they are discharged.3.Conventional treatment group(control group): complete all scales and lung function testing on admission,according to the guidelines,using basic treatment,including respiratory support,oxygen,drug treatment such as anti-infection,expectorant and anti-inflammatory,they are forbidden to do any pulmonary rehabilitation duration hospitalization.then complete all scales and lung function testing when they are discharged.4.All the data was operated with SPSS22.0 statistical analysis software,using Mann–Whitney U test to comparing the difference between the two groups,using the Spearman’s rank test to comparing the linear correlation analysis between the two indicators.Onsults The chronic obstructive pulmonary disease Assessment Test(CAT)、Modified Medical Research Council(m MRC)、Borg scale score(Borg)are all decrease after treatment in both pulmonary rehabilitation group and conventional treatment group,and the six-minute walk test(6MWT)is increase in both group;and the change in pulmonary rehabilitation group is more obvious;the change of lung function index before and after treatment in tow groups has no obvious diffence.There is no significant difference in the average days of hospitalization between two groups.Conclusions It is safe and feasible to run this pulmonary rehabilitation exercise in hospitalized patients with AECOPD early,cooperate with breathing training,health education,and without adverse events,it can reduce the symptoms of dyspnea,improve exercise capacity and the quality of life,But compared with the conventional treatment group,there were no significant differences in terms of improvement of lung function,and can not reduce the average days of hospitalization. |
