| Methamphetamine(METH)addiction is a pathological process of learning and memory.Addiction memory is one of the key factors leading to relapse among METH abstainers.Previous studies have explored to " eliminate or suppress" this memory,and found that retrieval-extinction behavior therapy and other methods can effectively interfere with addition memory.However,we need to find new treatment to intervene in these memories because it is hard to eliminate these memories completely.METH can rise dopamine in the synaptic cleft sharply,addicts experience a strong euphoria which forms the emotional part of the addiction memory.Aerobic exercise can also promote the release of dopamine and produce pleasant emotional experience.Previous studies have suggested that exercise may be an alternative tool to suppress the craving of drug in the early stage of addiction.Then,is it also an alternative tool to suppress the addiction memory for addicts? What are the characteristics of addiction memory? Which exercise intensity can addicts experience more pleasure? Can long-term aerobic exercise intervention form motor emotional memory and weaken the emotional part of the addiction memory? Based on the previous research,the present research will explore the above problems through five experiments.In experiment 1,we used Event Related Potential technology to explore the emotional characteristics of addiction memory.In experiment 2,we also use ERP to explore whether the abstainers have enhanced addiction memory.In experiment 3,we aimed to found the more pleasure induced exercise intensity through the Emotional State Scale and the Physical Activity Enjoyment Scale.Besides,we also explore the difference impact of moderate and high intensity acute exercise on addiction memory.In experiment 4,we aim to explore the impact of moderate acute exercise on the addiction memory and sports memory.In experiment 5,we use ERP to explore the impact of long-term moderate exercise on the addiction memory and sports memory,and also the impact of long-term moderate exercise on the anxiety state.The results showed that:(1)In Experiment 1,the reaction time and the ERP component EPN(Early Posterior Negativity)showed that there was no significant difference between drug and positive pictures.Means that abstainers have the similar reaction to drug and positive stimuli;(2)In Experiment 2,behavioral data showed that the recognition ability of drug picture was significantly higher than that of neutral picture(p < 0.001);EEG data showed that the average amplitude of P2(p = 0.007)and difference wave(p = 0.015)induced by drug picture was significantly higher than that induced by neutral picture.;(3)In Experiment 3,PAES scores showed that the pleasure got from moderate intensity acute aerobic exercise was significantly higher than that of high intensity(p = 0.031);the self-evaluation score of emotional state showed that the pleasure after moderate intensity acute aerobic exercise intervention was significantly higher than that before exercise(p = 0.001),and the pleasure score before and after high intensity acute aerobic exercise intervention was not significant.The results of recognition task showed that the discrimination of high intensity exercise intervention was significantly higher than that of medium intensity exercise intervention(p = 0.019);(4)In Experiment 4,results showed that the discrimination of drug pictures(p = 0.021)and exercise pictures(p = 0.015)in the post-test of exercise group was significantly higher than that in the pre-test,while there was no significant difference in the control group;(5)In Experiment 5,the data of behavior index discrimination,EEG index P2 and differential wave of recognition task showed that only the discrimination(p = 0.001),P2(p = 0.009)and differential wave(p =0.028)data was significantly higher than the three indicators in the pretest,but there was no significant difference in the memory level of drug pictures in the exercise group before and after the test,and there was no significant difference in all indicators in the control group before and after the test;the score of anxiety scale showed that the state anxiety score in the exercise group after the test was significantly lower than that in the pretest(p = 0.050),while there was no significant difference in the control group.Conclusion:(1)there exist a positive addictive emotional memory in METH abstainers,and the emotional addiction memory of the abstainers was stronger and easier to retrieve than the general memory;(2)Moderate and high intensity of acute aerobic exercise can effectively improve the recognition memory level of METH abstainers,and the pleasure of abstainers is higher under middle intensity of acute aerobic exercise;(3)Long term moderate intensity aerobic exercise can form motor emotional memory,which may play a certain role in inhibiting addictive emotional memory and preventing relapse. |
PDF Full Text Request