| Misfolded prions (PrPSc) are well known for their resistance to conventional decontamination processes. The potential risk of contamination of the water environment, as a result of the disposal of specified risk materials (SRM), has raised public concerns. Ozone is commonly utilized in the water industry for the inactivation of microbial contaminants and was tested in this research for its ability to inactivate prions (263K hamster scrapie). With the applied ozone dose of 7.6-25.7 mg/L, the efficacy of ozone inactivation of PrPSc was both pH and temperature dependent. Treatment variables included applied ozone dose (7.6.25.7 mg/L), contact time (5 s and 5 min), temperature (4&... |
