Modulation of gamma-aminobutyric acid (GABA) type A receptor-mediated responses in spinal dorsal horn neurons by mu-opioid receptor agonists and calcium(2+)/calmodulin-dependent protein kinase and Monte Carlo simulation of the GABAergic synaptic transmiss

GABA is believed to be a major inhibitory neurotransmitter in the central nervous system. This work first used whole-cell voltage clamp technique the modulatory effects of ;We found that a bicuculline-sensitive GABA-induced current was predominantly potentiated by ;Intracellularly applied, the ;These findings suggest that in acutely isolated rat spinal DH neurons (and in hippocampal CA1 neurons), GABA;This study then used the Monte Carlo method to simulate the GABA...