| The discovery of effective chemotherapeutic agents for the treatment of human cancer has been a challenging area of research for the organic chemist. As part of our Institute research in the field we have found the 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo{2.2.1}heptane cation to exhibit remarkable antineoplastic activity. A series of anion derivatives of the 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo{2.2.1} cation were prepared and found to have significant cancer chemotherapeutic properties. In addition, a recently developed technique for mass spectral analysis based on solution phase secondary ion mass spectrometry, was successfully applied to the identification and structural confirmation of the new bicyclo{2.2.1}heptanes. |
