Font Size: a A A

Synthesis of fluorogenic probes for studying biomass degradation and synthesis of newantifungal aminoglycosides

Posted on:2016-06-01Degree:Ph.DType:Dissertation
University:Utah State UniversityCandidate:Zhang, QianFull Text:PDF
GTID:1471390017484247Subject:Organic Chemistry
Abstract/Summary:
For the first project, a library of fifteen commercially purchased and synthetic fluorogenic probes were employed for the investigation of biomass degradation using extract of white-rot fungi. These discoveries prove that it is possible to employ fungi for selective degradation or release of hemicelluloses from biomass. This work is supported by Sun Grant Western Regional Center/DOT "Bioprospecting for Enzymes to Break Lignin-Hemicellulose Bond" (;The second project is focused on synthesizing new aminoglycoside analogs and exploring the potential to revive traditional antibacterial kanamycin as new type of antifungal agents. Although aminoglycosides antibiotics are mainly used as antibacterial agents, this project prove that it is possible to convert kanamycin to amphiphilic antifungal agents through simple chemical modification.
Keywords/Search Tags:Project, Biomass, Degradation
Related items