| Effects of platelet-activating factor (PAF) and U46619, a thromboxane A;Intrahepatic portal vein administration of U46619 to anesthetized rats produced dose-dependent increases in hepatic portal pressure and blood glucose concentration, which were inhibited by the selective TxA;Administration of sensitizing antigen to sensitized rats and isolated perfused livers produced hepatic responses which were similar to PAF-induced responses in rats, and which were inhibited by selective PAF receptor antagonist, WEB2086. Infusion of ovalbumin into isolated perfused livers produced increases in hepatic PAF and TxA;In summary, these observations provide evidence that PAF and TxA... |
