Research On Syndromes Elements Characteristic And Syndromes Standard Of Type 2 Diabetes Mellitus

Objective:To explore the distribution, variation, combination and the essence of syndromes elements of Diabetes Mellitus (SEDM)Methods:1. Literature research:To systems review literature existed in the past and recent years,to recognize distributions and the progression of SEDM 2.Clinical and experimental research:Combination with the investigation, diagnosis measurement of Traditional Chinese medicine (TCM) and multiple statistical analysis, to research 518 patients with common elements and following derivation of SEDM IN Changsha City. At the same time, the correlated indexes of 116 example of that sample were selected to discover the essence of SEDM by correlative research between multi-index and multi syndromes elements.Results:1.Literature research:the methods of differentiation of syndrome was known by complete revisewing all the past literatures, to know that of nowadays have developed to differentiate syndromes in accordance with the nature of diseases (Qi, blood, Jinye,) and the cause of diseases (phlegm-dampness?stagnancy of live-qi?hotness) out of traditional triple diadetes differentiation of syndrome.The types of syndrome are different. To differentiation syndrome according to the disease and differentiation symptoms according to syndrome it is not accorded with the clinical thinking of differentiation of syndrome,and also couldn't satisfied with the clinic need. Differentiation of syndrome accords with the Gestalt Principle of System Theory, and could reflect proximately the characters of diabetes Mellitus(DM).2. Clinical research:Through clinical research, using the method of counting-diagnosis of TCM. To research the distribution, combination of the elements of syndrome and the variation regular of syndrome of DM. The result:(1) Symptoms and physical signs:the typical symptoms of polydipsia, polyuria, polyphagie and maciationa,are 38.9percentage; ones of emaciation body are 10.6 percentage; ones of corpulent body are 41.7 percentage. (2) Variable clustering analysis:the common elements of syndrome of Dmare:deficiencyof Qi, deficiency of Yin, insufficiency of yang, biood stasis,phlegm-dampness and hotness. To every elements of syndrome has the principal component analysis to find the cardinal symptoms,subcardinal ones. (3) Distribution regular of elements of syndrome:deficiency of Qi and Yin are in every phase, especially; blood stasis is present following with other complications; phlegm-dampness and hotness are present most frequently without complications; deficiency of Yang is present usually in later stage of serious complications. (4) Combination regular of elements of syndrome:the syndrome DM distribute widely the combination of elements are complicated, DM without complications usually is the complication of two,three or four syndrome,when with complications, usually is the complication of three, four or five syndrome,the more serious, the more complicate of the complication of elements. (5) According to the character of distribution and combination of the SEDM in every phase:to think Insufficiency of spleen is primitive factor of DM.1.Clinical experiment research:(1) The phlegm-dampness syndrome of DM type 2 patients has the character of Hyperinsulinism (FINS,2PINS are all hing); hyper-lipoproteinemia(TG, TC, LDL-C, LP(a)are all high);Insulin resistance(Homa-IR are high);obesity (BMI,WC are both high).To compare with other groups, the difference is significant.It shows that the combination of the indexes mentioned above can be used as the objective evidence for the differentiation of phlegm-dampness syndrome. (2)The index of heart function can be used as one of reference indexes to different deficiency of Qi and deficiency of Yang. (3) CAMP CGMP and their proportionalit can be used as one of objective indexes to different excess syndrome and deficiency syndrome, deficiencof Yin and Yang.Conclusions:1. according to variable ciustering analysis,the common syndrome's elements of DM are:Deficiency of Qi, Deficiency of Yin, insufficiency of yang,Blood stasis, phlegm-dampness and hotness.2. The distribute and combination of syndrome's elements are very complicated,the combination of several syndrome's elements is major, Deficiency of Qi and Deficiency of Yin are present in every phase of DM.3. The relationship between indexes and syndrome is not linear relation,several-factors treating is the new method for the research of syndrome's elements.