Association Of LACC1,CEBPB-PTPN1,RIPK2,and ADO-EGR2 With Ocular Behcet's Disease In A Chinese Han Population

Background:An Immunochip study recently identified the association of a number of new genetic loci with Behcet's disease(BD).Objective:To confirm the association between new genetic loci reported in an Immunochip study and BD in a Han Chinese population.Methods:A two stage association study was carried out in1238 BD patients and 1458 healthy controls.Twenty-two candidate single nucleotide polymorphism(SNPs)were selected for genotyping by iPLEXGold genotyping or TaqMan SNP assays and a meta-analysis was also performed for significantly associated markers.Results:The results showed that four SNPs(LACC1/rs9316059,CEBPB-PTPN1/rs913678,ADO-EGR2/rs224127,and RIPK2/rs10094579)were associated with BD in an allelic association test(rs9316059 T allele,P_c=4.95×10^-8,odds ratio(OR)=0.687;rs913678 C allele,P_c=3.01×10^-4,OR=1.297;rs224127 A allele,P_c=3.77×10^-4,OR=1.274;rs10094579 A allele,P_c=6.93×10^-4,OR=1.302;respectively).For 4 SNPs tested by meta-analysis,the association with BD was strengthened and all exceeded genome-widesignificance(rs9316059,P=2.96×10^-16;rs913678,P=2.09×10^-16;rs10094579,P=9.21×10^-11;rs224127,P=5.28×10^-13;respectively).Conclusions:Our findings confirmed the association of four loci(LACC1,CEBPB-PTPN1,ADO-EGR2,and RIPK2)in Chinese Han patients with BD.