The Preparation Of The Mn(Ⅱ) Complexes With Chiral Marocyclic Polyamines And The SOD-like Activities

Superoxide dismutases have the ability to catalytically dismutate superoxide, which has many potential applications in the research fields of medicine, sanitation and pesticides. However this kind of applications are seriously hindered by the common properties of high molecular weight and high expense. Therefore, many efforts have been devoted to design and synthesize various superoxide dismutase mimics (SODm) with small molecular weight, ease preparation, low toxicity and high activity. Here, we design and synthesize six chiral marocyclic polyamines as SODm and test their SOD-like activity. The main research contents are listed as the following:1. Two 4-chloro-diacylpyridine intermediates were synthesized by one-pot method, and the reaction process was monitored and optimized by gas chromatography. Comparing the reported synthetic route, this kind of synthetic method has the advantages of short route, high yields. Their structures were confirmed by ~1H NMR, GC-MS and IR. Among them, 4-chloro-dipropylpyridine is firstly reported here.2. Staring from 1R,2R-cyclohexadiamine and the synthesized 4-chloro-diacylpyridines, Six new chiral marocyclic polyamines were designed and synthesized. These chiral marocyclic polyamines contain chloro functionality on pyridine ring which can be derivatized further to obtain molecular assembly systems in the future. The structures of these compunds are shown as the following:...