Symmetry Analysis Of Palindrome In Human Y Chromosome

On June 19 , 2003, Nature magazine published the analysis result of the sequence of human Y chromosome DNA, revealed a great deal of peculiar and important discoveries of Y chromosome for the first time. The most noticeable one is the eight highly symmetrical DNA palindromes essential to male reproduction ability. These palindromes include 8 kinds of genes controlling testicle-development, gene mutation or deletions of certain DNA segments in these palindromes will cause spermatogenic failure. These DNA palindromes have special symmetrical characteristics, they may have played an important role in keeping relative stability of genes in the course of man's long evolution, repaired mutation through gene conversion.It is the greatest challenge that we face at present to understand the symmetries and the symmetry-break mechanisms of DNA palindrome and the informations contained in them. This text is mainly about the analysis of the palindromes of Y chromosome. We mainly used DOTTER program for detailed comparison of two sequences to obtain these results. The main contents are as follows:Chapter one mainly introduces the whole characteristics of human Y chromosome;Chapter two mainly describes the characteristics, functions andrecombination modes of the palindromes in Y chromosome;Chapter three mainly analyses the symmetries of 8 palindromes of Y chromosome, we find a mechanism of symmetry breaking in P2 palindrome from a detailed analysis;initially introduces other 7 palindromes.