Preliminary Observation On Differentiation Of Hair Follicle Stem Cells Into Corneal Epithelial Cells

Stem cells are generally slowly cycling, but they have a high proliferate potential at times of tissue expansion, such as during fetal development and wound healing. As an appendix organ appendage of skin, hair follicle plays an important role of skin self-renewing, hair growth and tumor origin. Previous studies discovered that Slow-Cycling High proliferate potential cells of hair follicle were localized to the prominent bulge region which is located below the opening of the sebaceous duct and serves as the attachment site of arrector pili muscle. Recently experiment demonstrated that bulge-located stem cells can not only migrate to the upper part of the follicle to generate sebaceous glands and epidermis, but also give rise to many of the compartments of the lower follicle, including the lower outer root sheath, matrix, and the medulla.Keep corneal epithelial integrity is very important to maintain its normal physiological function and pellucidit. many etiological factor cause repeatedly epithelia defect,erosion,ulcer and angiogenesis, and lead to pterygium and corneal labrum deletion. To solve these problems, we must reconstruct corneal epithelium. The corneal epithelium has good proliferating ability under normal conditions, because of exiting corneal limbus stem cells in the corneal limbus basal layer, corneal limbus stem cells are the origin for corneal epithelial proliferation and differentiation. However, in many pathologic conditions corneal epithelial deletion were to exceed corneal limbus stem cells proliferating ability, and may undergone immunologic rejection if transplant allogenic corneal limbus stem cells. For the past few years, a great deal experiments manifested that somatic stem cells have the potential of transdefferentiation, and their microenvironment (or niche) is an essential factor. Corneal stroma, as the niche of corneal limbus stem cells and corneal epithelial cells, can keep theirs property. Stroma cells secrete many factors which accelerate cell proliferate and form network adjustment to directional differentiation of cells. On these grounds, we...