| Deoxyribonucleic acid not only bears heritage information, but also instructs the biological synthesis of proteins and enzymes through the replication and transcription of genetic information in living cells. Many complexes have been studied and used as DNA structure probes, DNA molecular light switches, cleaving reagents, chemotherapeutant and so on, and show great potential.This paper research the interaction between the complexes and DNA by changing the ancillary ligands (bzH, phen, ipH and 8-HQ) and insert ligands (CPIA, bdipH and CIP). The different complexes ([Co(phen)2(CPIA)](ClO4)3·2H2O, [Co(phen)2 (bdipH)](ClO4)3·2H2O, [Co(phen)2(CIP)](ClO4)3·2H2O, [Co(ipH)2(bdipH)] (ClO4)2·2H2O, [Co(8-HQ)2(bdipH)]·H2O, [[Co(phen)(bzH)(bdipH)Cl]Cl·2H2O, [Ni(phen)(bzH)(bdipH)Cl]Cl·4H2O, [Co(phen)(bzH)(p-mopipH)Cl]Cl·2H2O and [Ni(phen)(bzH)(p-mopipH)Cl]Cl·3H2O) have been synthesized. Binding properties of the three complexes with calf thymus DNA have been investigated by spectroscopic methods, cyclic voltammetry and viscosity measurements. The experimental results indicate that complex with carboxyl binding with DNA is not strong, and the size and shape of the intercalative ligands have significant effects on the binding affinity of complexes to calf thymus DNA. And auxiliary ligand steric also effect DNA binding with complexes.
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