Applications Of Natural Rubber Latex Material Catalyzed By Transglutaminase

Biomedical Materials promoting the contemporary materials science has become an important development direction. With the research and development of biomedical materials, regeneration and reconstruction of damaged human tissues and organs, to restore and enhance the body's physiological function, personalization and minimally invasive therapy have become more and more important for the 21st century which is a period of life sciences and health industries.Natural rubber latex is a natural polymer water-based gel system which involves the cis-regulatory 1.4-isoprene as the main component, including the water-soluble proteins, which can increase the mechanical stability of the natural rubber. Water-soluble proteins contained in natural rubber latex are potent allergens capable of inducing potentially fatal anaphylaxis. Up to now, great many ways have been found to reduce protein content in natural rubber latex, such as drain filter, centrifugal purification, surface treatment (chlorination, enzyme LOPROL, HDPNR), radiation, and so on. However, the effect is not satisfactory.Microbial Transglutaminase (MTGase), considered being stable over a wide pH range and been applied on food manufacturing, can modify latex proteins by the covalent incorporation which maintain or increase the stability of natural rubber latex. The major impact factors were optimized by using response surface methodology. Moreover, the mechanical ability of natural rubber latex modified by MTGase was obviously enhanced.