Studies Of Voltammetric Behaviors And Applications Of Thiol Derivatives At Silver Microdisk Electrode

Thiol derivatives were of particular interest in biosphere and synthetical chemistry because of their physiological properties and their importance as chemical materials.The silver microdisk electrode was prepared and utilized to study the electrochemical behaviors of some thiols. It had been observed that there were sensitive voltammetric responses of most of thiols at silver microdisk electrode.In this thesis, we studied the electrochemical behaviors of reduced glutathione, the degradation products of glutathione and 6-mercaptopurine at silver microdisk electrode in detail. In the negative potential range (for example from 0.1V to -1.0V), there was a sensitive cathodic peak at -0.65V, -0.47V and -0.81 respectively on the cyclic voltammograms of reduced glutathione, the degradation product of glutathione and 6-mercaptopurine. Under the proper condition, the cathodic peak currents were proportional to the concentrations in the range of 1.0X 10-5-1.0X 10-3mol/L , 9.0 X 10-7-4.0 X 10-5mol/L and 1.0 X 10-8-2.0 X 10-6mol/L respectively. The method had been successfully applied to determination of the thiols in simulant samples.On the other hand, we have also studied the electrochemical behaviors of other thiol derivatives with the silver microdisk electrode, such as 1,4-dimercaptomethyl benzene, degradation product of cefotaxime and thioglycolic acid, and obtained some useful information.At last, we modified silver microdisk electrode by 6-mercaptopurine and earned gut some abecedarian studies of its electrochemical behavior.