| The studies of speciation analysis of trace arsenic in Traditional Chinese Medicine by hydride generation-atomic fluorescence spectrometry are reported in this paper, which consists of five chapters.Chapter one: The recent progress on the speciation analysis of trace elements in Traditional Chinese Medicine has been reviewed with the relative references of 62.Chapter two: A method has been described for the determination of arsenic by hydride generation-atomic fluorescence spectrometry (HG-AFS). The experimental conditions that influence the atomic fluorescence intensity and the reduction of arsenic were investigated and optimized, and the influence from foreign ions and the elimination were studied. The detection limit and relative standard deviation (RSD) were of 90.5ng/L and 1.38%, respectively. The proposed method was applied to the determination of arsenic in eleven kinds of Traditional Chinese Medicines produced by different manufactures with a recovery range of 90.7-108.9%.Chapter three: A method has been described for the direct determination of arsenic species (arsenite, arsenate) in Traditional Chinese Medicines using hydride generation-atomic fluorescence spectrometry (HG-AFS). The experimental conditions that influence the fluorescence intensity and the reduction of arsenic were investigated and optimized, and the influence from foreign ions and the elimination were studied. The detection limit of 89.1 ng/L was obtained. The proposed method was applied to the determination of arsenic species in water leachate of Traditional Chinese Medicine with a recovery range of 91.0-109.5%.Chapter four: A method for the determination of arsenic species (arsenite, arsenate) in Traditional Chinese Medicines using hydride generation-atomic fluorescence spectrometry (HG-AFS) with anion exchange resin separation has been studied. The anion exchange resin was used to separate arsenite and arsenate. The separation conditions were investigated and optimized. The experimental conditions that influence the fluorescence intensity and the reduction of arsenic (V) wereinvestigated and optimized, and the influence from foreign ions and the elimination were studied. It was applied to the determination of arsenic species in water leachate of Traditional Chinese Medicines. The detection limit ol 89.1 ng/L and a recovery range of 91. 1-109. 3% were obtained.Chapter five: A method has been described for the determination of arsenic species (arsenite, arsenate and dimethylarinic acid) in Traditional Chinese Patent Medicine by hydride generation-atomic fluorescence spectrometry (HG-AFS) using separation with ion-exchange resin column. The extraction of arsenic with mechanical shaking, the separation of arsenic species with ion-exchange column and the influence of experimental conditions on the fluorescence intensity were investigated and optimized. The detection limit was found to be 104.0 ng/L. The proposed method was successfully applied to the determination of arsenite, arsenate and dimethylarinic acid in Traditional Chinese Patent Medicine with a recovery range of 90.8- 110.2%.
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