Study On The Appropriate Conditions For Salt Effect By Combined Experiment Design Method

The combined experiment design method is proposed after comparing and contrasting the orthogonal design method and the uniform design method. It's able to use for determining the appropriate conditions of those experiments containing the noncontinuous factors who can not be expressed with function and the continuous factors who can be expressed with function.The proposed method contains two main parts: one part is determination of the noncontinuous factors by the orthogonal design method and the other is determination of the continuous factors by the uniform design method.Application of the combined experiment design method to ethanol-water system has shown it's able to use for determination of the appropriate conditions for salt effect in extractive distillation with salt of binary close boiling or azeotropic mixtures. Under the appropriate conditions of sampling equipment of gas chromatographic headspace analysis, determine a suitable salt and a suitable extracting solvent by the orthogonal design method, then determine the fitting feed composition of ethanol-water mixture, the fitting distribution between extracting solvent and mixture, and the fitting salt concentration by the uniform design method. Application of the proposed method can lead to the anticipant experimental results and also decrease the experimental work largely.