Study On The Synthetic Technology Of α-Lipoic Acid

α-lipoic acid is an essential coenzyme in the oxidative decarb-boxylation of α-keto carboxylic acids. In addition, because of its special structure, a -lipoic acid has been proved to be effective anti-oxidant, widely used in pharmacology.Since firstly isolated by Reed in 1951, many researchers in this field have studied its synthesis. In this paper, on the basis of an improved method, a -lipoic acid has been prepared. Besides, the spectrum characteristics of intermedieates and products have been analysised. Reaction mechanisms and conditions are discussed. A lotof valuable results are obtained. The main research work are as follows:一,The whole route has been carried out.α-lipoic acid is prepared. Every step has reached or exceeded those in documents.二, After hundreds of reactions, every step of this route are deeply and carefully discussed. The main reaction factors, such as reaction time, material proportion are entirely discussed , analysised, compared and concluded. So the most desired industrial conditions are selected. The experimental results laid solid theoretical foundation for larger scale reaction.三, The specific mechanism of every step of this route are discussed.四,Intermediates of every step are boldly and validly separated. The treating methods of products are improved.五,The products' spectrum characteristics are discussed. These collected datas offer appraisal references to research and industrial-lization of a-lipoic acid.