| Sulfasalazine is a kind of antibacterial drug, which works inside the bowel by changing the bacteria group and reducing antigen of the body. Sulfasalazine is used to prevent and treat inflammatory bowel disease, such as ulcerative colitis, and rheumatoid arthritis. Its gold(I) and copper(II) complexes also have pharmacological actions, however their crystal structure have not been reported . Seven crystal structures have been obtained by treatment sulfasalazin with alkali-earth metal salts ,Pb(NO3)2,Co(O Ac)2 .4H2O,Zn(OH)2 and Zn(OAc)2, respectively. The condensation of salicyaldehyde with 2-aminothiophenol resulted in benzothiazoly derivates, which, when reacted with some metals, yields a complex in which the ligand usually establishes the rupture of the thiazole ring (along the C-S). This paper reports the coordination reaction of the benzothiazoly derive with Cu(I), obtained a complex, in which thiazole ring does not appear rupture. The crystal structure is determinated.Crystallographic data for the ligand sulfasalazine: C36H42O19N8S2Cl, Mr = 990.35, belongs to the triclinic crystal system, space group P-1, cell parameters: a = 11.5878(7), b =15.0294(9), c = 15.3792(9)?, α = 113.119(1), β = 109.331(1), γ = 92.447(1)?, V = 2280.6(2)?3, Z = 2, Dc = 1.442Mg/m3, R1 = 0.1214, wR2 = 0.2499. In an asymmetry unit, there are two deprotonized sulfasalazines, one chlorine ion and nine lattice waters. The reactions of sulfasalazin with alkali-earth metal (Mg(II), Ca(II) and Sr(II)) salts afford three sulfasalazin alkali-earth metal compounds. Compound (H-Sulp)[Mg(H-Sulp)(H2O)5]·5H2O(1), C36H46MgN8O20S2, Mr = 999.24, belongs to the triclinic crystal system, space group P-1, cell parameters: a =11.1516(13), b = 15.4471(19), c = 16.0471(19)?, α = 115.654(2), β = 107.909(2), γ =91.861(2)?, V = 2326.4(5)?3, Z = 2, Dc = 1.426Mg/m3, R1 = 0.1298, wR2 = 0.2585. Compound (H-Sulp)[Ca(H-Sulp)(H2O)6]· 3H2O (2), C36H44CaN8O19S2, Mr = 996.99, belongs tothe triclinic, space group P-1, cell parameters: a =11.5786(11), b = 15.0224(15), c = 15.3953(15)?, α =113.129(2), β =109.302(2), γ = 92.477(2)?, V = 2277.5(4)?3, Z = 2, Dc = 1.454 Mg/m3, R1 = 0.1423, wR2 = 0.2966. Compound (H-Sulp)[Sr(H-Sulp)(H2O)6]·3H2O(3) ,C36H44SrN8O19S2, Mr = 1044.53, belongs to the triclinic, space group P-1,cell parameters: a = 11.583(2), b = 15.128(3), c = 15.518(4)?, α = 113.19(1), β = 109.18(1), γ = 93.30(1)? , V = 2305.4(8)?3, Z = 2, Dc = 1.505 Mg/m3, R1 = 0.0592, wR2 = 0.1243。 These three crystals are all ionic complexes, the centeral metal Mg(II) of complex 1 adopts six-coordinated distorted octahedral geometry. Ca(II) for compound 2 and Sr(II) for compound 3 adopt seven-coordinated capped octahedral geometry. Among these compounds, carboxyl of ligand is monodentate and N atom of pyridine doesn't participate in the coordination. In addition, there are a large number of strong hydrogen bonds and weak hydrogen bonds in compound 1, 2 and 3, which result to form 3-D supramolecular structures.Lead is a main group toxic heavy metal elememt. A novel 1-D coordination polymer [{Pb(H-Sulp)2(H2O)}·2H2O·CH3OH]∞(4) has been obtained by the reaction of Pb(NO3)2 and sulfasalazin. Its crystal data: C37H32PbN8O14S2, Mr = 1084.02 monoclinic, space group P21/c, cell parameters: a = 20.485(2), b = 26.374(3), c = 7.6331(9)?, β=95.424(2)?, V = 4105.6(8)?3, Z = 4, Dc = 1.754 Mg/m3, R1 = 0.0990, wR2 = 0.2412. Pb(II) adropts six-coordinated octahedral geometry. The carboxylate group of ligand acts as both monodentate and terdentate modes to coordinate to Pb(II). carboxyes The crystal structure of compound 4 contains Pb-O-Pb-O rhomboidal units formed through the two bridging O, in which the Pb-Pb distance is 4.04?. The ajacent Pb-O-Pb-O rhomboidal units are linked by Pb-Pb weak directed bonding with Pb-Pb distance of 3.626? and results in a 1-D infinite structure. A large number of hydrogen bonding interactions in the pack of compound 4 forms 2-D netwok strucutre, which may play important role for stablizing the compound. Through t...
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