Synthesis Of Imidazolinone Compounds And Tetrahydroisoflavone

This paper is composed of two parts.Part one is the synthesis of imidazolinone compounds. Imazapic, Imazapyr and Imazamox are highly effective, low toxic and environments kindly Imidazolinone herbicides which have not been produced in our country. Using ethyl chloracetate and diethyl oxalate as starting materials, Imazapic was synthesized via condensation, cyclization and other steps. The total yield is 40.3% which is slightly higher than that in the patent, Imazapyr was also successful prepared through oxidation and cyclization using 8-hydroxyquinoline as the main reactant, and the content of effective isomer is higher than that in the patents. In addition, some exploration was conducted for the preparation of Imazamox.Part two is the synthesis of tetrahydroisoflavone. Isoflavone, useful as one of effective components of many Chinese herbal medicine, possessing some specialpharmaceutical use. Therefore, a new precursor of isoflavone--5,6,7,8-tetrahydroisoflavone, was synthesized by a novel method using heptanedioyl dichloride and the enamine derived from phenylacetaldehyde. And this enlarged the applied range of Stocker enamine reaction.