The Preparation Of Wide Table Dust And Mite's Inhibitor And The Research Of The Effect Of Preventing Them

Because the indoor dust and mite often disappears in the each place of daily life at home and it is the factor of various allergies, so that, the prevention and cure of dust and mite is suffered the extensive concern of the international community researcher.Pyrethroid is a kind of insecticide of efficiently killing and low poison, in recent years, the stability of bearing the hot and the weather of pyrethroid is all good, so pyrethroid can be fit to be used as the anti-dust and mite finishing agent on the fabric if it can be efficiently knocked-down the toxicity for mammals.Through the structure analysis of the known pyrethroid, we designed and synthesized a new series of pyrethroid-N-aryl valine series pyrethroid insecticides, and proceeded the living creature activity test for them.The synthetic methods are as follows:1. The compounds were prepared by using isovaleric acid as starting material through acyl chlorination,bromination, esterification and animation in overall four steps.2. We prepared the compounds using isovaleric acid as starting material through brominaton(HVZ reaction),amination and esterification in an overall three steps.The key step of the two routes is the reaction of nucleophilic substitution of aromatic amines and -bromo compounds. Generally the produce rate of this reaction is low and the reaction time is long. In order to improve the produce rate, we studied the effect of choosing the different solvents on the produce rate of the reaction of nucleophilic substitution, and we added a litttle catalyzer at the same time; in order to shorten the reaction time, we tried to put the supersonic wave on the yield of thereaction, and we got the better effect.The living creature activity of pyrethroid is various, thereof the lethal effect is the first consideration in regard to the result of killing dust and mite. We analyzed the lethal effect of the compounds by determining the median lethal concentration LC50 of power dust, and the result showed that the prepared compounds were effective for power and dust, thereof some compounds had the prominent effect.