Application Of Indium Reagents In Organic Synthesis

This thesis described two easy accesses to synthesize branched and linear homoallylic alcohols. Branched homoallylic alcohols were obtained in moderate to good yields using indium-mediated allylation reactions with 2-phenyl-4-bromo-2-butene in mild condition. On the other hand, linear homoallylic alcohols were obtained using allylic transfer reactions with excellent diastereoselectivities and good yields.In addition, both the a-homoallylic alcohol and γ-homoallylic alcohol were employed to react with aldehydes. The results showed that only the reaction of a-homoallylic alcohol exhibited good selectivities. Then both the E type a-homoallylic alcohol and Z type a-homoallylic alcohol were employed to investigate the scope and mechanism of the intramolecular oxonium-ene cyclization reaction. The products exhibited excellent yields with moderate to good selectivities.