Study On Pharmaceutics Of Quick Result Resist Heat Stroke

pharmaceutics of quick result resist heat stroke is adjusted from the ZhuGeXinJun powder through prescription screening. It is more effective for the prevention of heat Stroke. Objective:1) To obtain a new prescription which is more suit for spray on the base of the prescription of ZhuGeXinJun powder.2) To develop a assay method for Muscone and cholalic.3) To screen the best extract technique for Volatile oil, cow-bezoar and Musk.4) To screen a moulding technique.5) To enact a quality criterion. Methods:1) Heat exposure rats which have been treated with several different methods in phytotron (41?, relative humidity 70%), estimated the death time and the temperature from the anus of the rat, and then compare the difference of the temperature, survival data and mortality between the Preventive heat Stroke Spray and the ZhuGeXinJun powder.2) Using the GC method to assay the content of Muscone, using the UV spectrophotometer to assay the content of cholalic acid.3) Orthogonal design was used to screen the best extract method and moulding method for Volatile oil, Musk and cow-bezoar.4) Using developed content assay methods to estimate the contents of Muscone and cholalic acid. Thin layer chromatogram scanner was used to qualitative Identificate the borneo camphor Pogostemon and dried ginger.Results:1) Preventive heat Stroke Spray is better for decreasing the temperature, amelioration survival data and decreasing mortality than theZhuGeXinJun powder in a low-heat enviroment.2) The linear regression equation and correlation coefficient of content assay methods for Muscone is y=-0.00114+1.099x109 , R=0.9999. and the linear regression equation and correlation coefficient of content assay methods for cholalic acid is y=-0.365+18.86x (ug/ml) R=0.9999. The callback rate for Muscone is 98. 88-101. 71% .The callback rate for cholalic acid is 99.41- 102.03%. All the RSDs of stability, precision and reduplication for both Muscone and cholalic acid are less than 1%.3) The best extract technique for Pogostemon dried ginger Volatile oil ,cow-bwzoar and Musk is stilling Pogostemon and dried ginger Volatile oil with ten times quantity ree for 7 hours; ultrasound extraction cow-bwzoar twice times with 20 times Chloroform, each tune is 20minutes; ultrasound extraction Musk twice times with 20 times acetic ether, each time is 20minutes.4) The content of Musk is 0.0493-0.0553mg/ml. The content of cholalic acid is 0.3974-0.5227 mg/ml. Both contents are between Oral drug preparation and parenteral solution and its suits for norm of Spray.Conclusion:Through the screening of prescription ,extraction methods and mouding methods, we get the end product of Preventive heat Stroke Spray .All the assay results show the prescription is reasonable, the effect is significant, the technique is feasible and its quality can be controlled . All above has done a foundation for the next study.