Studies On Leptopus Chinese Pojark And Synthesis Of Phosphoric Esters Of Flavones

Leptopus Chinese (Bunge) Pojark, a herb of Euphorbiaceae, is widely distributed in China , namely Hubei, Hunan, Guangxi , Sichuan and Yunnan. Its branches and leaves have long been known as a herbal medicine by local people to treat several kinds of disease, such as abdominal pain, malnutrition due to parasitic infestation and even paralysis. In Yuzhou of HeNan provence it was used to treat cancer. Initial pharmacological experiments showed a degree of inhibition to the growth of cancer cells. It's chemical components of this oriental medicine were studied here. The alcoholic extraction of this oriental medicine was respectively extracted by petroleum ether, ethyl acetate and water. The portion of petroleum ether was condensed to ointment by reduction pressure then the ointment was analysised by silica chramatagraphy. Three compounds were achieved namely friedelin (compd.l), 3a-hydroxyfriedelan-2-one(compd.2) and friedelane-2a,3p-diols(compd.3). The portion of ethyl acetate was analysised by silica chramatagraphy and two compounds were achieved namely triacontanol(compd.4) and p-sitosterol-3-O-p-D-glucoside (compd.5). In order to confirm the structure of compd.3 it's ethyl acetic ester(compd.6) was achieved via acylation. In the portion of petroleum ether a white lamellar mixture (compds.7) was achieved which was identified as the mixture of P-sitosterol and stigmasterol. In short in the work seven compounds were extracted and analyzed by IR MS, NMR. The strcture of compd.2 was even confirmed by X-ray analysis. All the compounds were firstly extracted from Leptopus Chinese (Bunge) Pojark except for compd.2 and compd.4.