The Synthesis, Characterization Of 2-(2-amino-4-thiazolyl)-2-(Z)-methoxyimino Acetic Acid, Ceftadine Side Chain Acid And Their Schiff Base Complexes

＝大Schiff base complexes is an important branch of mental-organic complexes. A series of its uses and concernful characters are noticed so widely that it becomes a very active subject in science nowadays. The number of Schiff base complexes is numerous, they are obtained through changing different compounds including carboxyl and nitric groups, they could be chain or ring and monadenate or didenate. Here , the middle productions of ceftadine 2-(2-amino-4-thiazolyl)-2-(Z)- methoxy iminoaceticacid (HL1) and2-(2-amino-4-thiazolyl)-2-[[(Z)-l -(t-butoxycarbonyl)-l, 1 -dimethoxy]imino]aceticaci d (HL2) were organic compounds including carboxyl and nitric groups. Four complexes which were derived from HL1, HL2 ,rare earth Sm (HI) and uranyl nitrate were studied and characterized; HL1 and HL were used to reacted with formsalicylaldhyde to form new Schiff bases HL , HL4 . Four complexes which were derived from HL3, HL4, rare earth Sm (III) and uranyl nitrate were studied and characterized. These complexes' coordination ways were studied as well.The thesis consists of the following four parts.1. The improved technology of productions HL1 and HL2HL1 is synthesized used ethyl acetoacetate as raw material by a step of oximation, methylination, bromination, and cyclocondensation. The inproved technology is include of using domination insteading of bromination and using poly glycol as catalyst. Its total yield is 63% which is higher than 60% reported, and its content is higher than 99%. The improved technology simplified the operation ,and reduced the production cost as well.Acetacetic ester is the main raw materials of the synthesis of HL2 , (Z)-2 -amino- a -(hydroxyimino)-4-thiazole acetate is achieved firstly. Its total yield is 65%, then the available synthesis route of HL2 was designed , and the samples of HL2 (>99%)was gained with a yield of 81%. Then HL'and HL2 were characterized by Infrared spectrum analysis and 1H NMR spectrum analysis.2. The synthesis of ligands and complexes derived from HL1 and HL2ABSTRACT(1) The synthesis of ligandsTwo new ligands (NaL1) and (NaL2) were gained by counteracting HL1 and HL2, these two ligands condensated with salicyladehyde formed another two Schiff base ligands NaL3and NaL4.(2) The synthesis of complexesThe two ligands (NaL1)and (NaL2) reacted with rare earth Sm (III) (ligand: mental ion=3: 1) to form two new complexes. The compositions of the two complexes wereSm (L1) 3 and SHI (L2) 3.The two Schiff base ligands ( NaL3) and ( NaL4 ) reacted with rare earth Sm (III) (ligand: mental ion=2: 1) to form two new complexes. The compositions of the two complexes were Sm (L3) 2andSm (L4) 2The two ligands (NaL1) and (NaL2) reacted with uranyl nitrate (ligand: mental ion=2: 1) to form two new complexes. The compositions of the two complexes wereUO2 (L1) 2 (CH3OH) andUO2 (L2) 2(CH3OH).The two Schiff base ligands (NaL3) and (NaL4) reacted with uranyl nitrate (ligand : mental ion=2: 1) to form two new complexes. The compositions of the two complexes were UO2 (L3) 2 (CH3OH) andUO2 (L4) 2 (CH3OH) .3. The characterization of these ligands and complexesThese ligands and complexes had been characterized by elemental analysis, Infrared spectrum analysis, 1H NMR spectrum analysis, Ultraviolet spectrum analysis or molar conductance analysis. Their coordination ways were studied. So their construction were presumed4. The antibacterial experimentation of these ligands and complexesThe antibacterial experimentation of these ligands and complexes were made. The ligands and complexes were used as antibacterial agents. The primary studies indicated that these complexes had stronger antibacterial ability than their ligands and they may be good antibacterial agents.