Synthesis, Characteristic Of Environmental Response Hydrogel And Its Application

How to improve such a series of performance as the response behavior, mechanics property the environmental response hydrogels by studying the hydrogel synthetic methods and performance is the main subject of this paper. On the basis of studying the performance of the hydrogel sufficiently, the hydrogels with good performance were choosed and probed into the application in such fields as bioseparation and mechanical valve, etc. Several sets of real models were designed and their behaviors were tested.N-isopropylacrylamide (PNIPA) hydrogels were synthesized by photo-polymerization, heat-polymerization, redox polymerization, and IPN methods. And their swelling, reswelling and deswelling properties were investigated. The result showed that the PNIPA hydrogels synthesized by various methods were all temperature-sensitive but their responsive rate and mechanics properties were different. Temperature-sensitive hydrogels has fine temperature-responsive reversibility, which after shrinking at higher temperature and can resume at lower temperature. This result is still very useful to hydrogel re-utilization. This is very valuable in the course of application of the hydrogel. Comparing the hydrogels synthesized by different methods, we choosed the hydrogel with good comprehensive performance and probed it into the application.On the basis of the research of the group have achieved, we have studied how to improve the response performance of the copolymerized P (NIPA-co-GMA-Dex) hydrogels with better intensity and biological compatibility. At first, the effect of the hydrogel scale to the responsive performance was tested. The result showed that with the decrease of the hydrogel scale, the hydrogel responsive rate was improved. On the basis of the research, the PNIPA hydrogel synthesized by redox polymerization was smashed and the temperature response performance was also observed under the microscope. The result showed that the minute hydrogel also has good temperature-sensitive properties and temperature-responsive reversibility. The response performance of the hydrogel did not wane much through eachcirculation of ascending and descending temperature. This outcome is very valuable to the application in minute instrument. At second, through adding the pore-foaming agent CaCO3 particle during the synthesis course, we found that the porous P (NIPA-co-GMA-Dex) hydrogel has better responsive performance than the conventional P (NIPA-co-GMA-Dex) hydrogels.According the preceding result, we probed the application of the two kinds of temperature-sensitive hydrogels in the bioseparation and mechanical field. The porous P (NIPA-co-GMA-Dex) hydrogel was choosed and the behavior of the hydrogel concentrating the BSA solution was also tested, the result showed that the porous P (NIPA-co-GMA-Dex) hydrogel could concentrate the BSA solution more effectively than the conventional P (NIPA-co-GMA-Dex) hydrogel. According the temperature-responsive reversibility of hydrogel, we tested the re-utilization ability of the P (NIPA-co-GMA-Dex) porous hydrogel during the course of concentrating the BSA solution. On the basis of the performance of the temperature-sensitive hydrogels, we designed three sets of mechanical models. Two of them were used to control the direction of fluid, and the other two models were used to concentrate BSA solution, Through testing the behavior of this three instruments, the feasibility of the hydrogel application in fact were proved.Poly-2-acrylamido-2- methylpropane-sulfonic acid hydrogels (PAMPS) and P (AMPS-co-AAM) copolymerized electric sensitive hydrogel were prepared respectively by photo-polymerization and heat-polymerization, and their responsive capabilities were also studied. Through the result of the experiments, PAMPS hydrogel has the better performance under the condition of lmol/L monomer (AMPS), 5mol% cross-linking agent (MBAA), initiator (KGA, 0.8mol%), and 4h illumination time. Compared with the PAMPS hydrogel, the P (AMPS-co-AAM) hydrogel have better mechanics performance but worse swelling and electric sen...