Studies On The Synthesis And Stereo-Structure Of Glycosyl Functional Compounds

As informational molecules, carbohydrates play essential roles in living organisms, including determination of antigenecity of molecules and phenotype of cells, recognition in many physiological and pathological events, and as signals of dynamic regulations and of regulation on time and space. Carbohydrate derivatives have been extensively investigated, including synthesis, characterization and biological activity, partly due to the facts that many naturally occurring saccharides and synthesized analogues exhibit various and potent biological activities, and have been widely employed as agrochemicals and Pharmaceuticals.In this paper, glycosyl has been inducted into the structures of thiourea, triazole, thiadiazole and triazine, using glycosyl isothiocyanates as intermediates. 30 compounds of three series of glycosides have been designed and synthesized, among them 25 compounds have not been reported in literature. Their chemical structures have been confirmed by means of elemental analysis, IR. Some of them have been studied by X-ray diffraction technique, and their crystal structures are reported precisely. Some properties of glycosides are also discussed here.The contents and the primary contributions of the research are summarized as follows:(1) A series of novel Schiff base compounds bearing glycosyl have been synthesized. The induction of life matter may efficiently improve their biological activities.(2) Investigation of the substitute modification of triazole[3,4-b]-1,3,4-thiadiazoles has long been the focus of drug synthesis. Inducting glycosyl to them is very important undoubtedly. Encouraged by all these observations, a series of novel glycosyl-triazole[3,4-b]-1,3,4-thiadiazoles have been synthesized.(3) The compounds bearing different groups, which have different biological activity, show high biological activities. Encouraged by all these observations, a series...