Studies On The Synthesis And Stereo Structure Of Glycosyl Compounds

In this thesis, glycosyl has been inducted into the structures of thiourea, diacylhydrazine, ferrocene, employing three monosaccharides including xylose, glucose and galactose as starting materials, and using glycosyl isothiocyanates as useful intermediates. Three series of glycosides have been designed, synthesized, and characterized by means of elemental analysis, IR and ~1H NMR. Three novel single crystals of glycosyl compounds have been successfully prepared and studied by X-ray diffraction technique. Their crystal structures are reported precisely, including bond lengths, bond angles, torsion angles and so on. Some properties of glycosides are also discussed here.The contents and the primary contributions of the research are summarized as follows:(1) Several novel highly symmetric carbohydrate compounds bearing diacylhydrazine framework have been synthesized via a five-step procedure, utilizing D-glucose, D-galactose and D-xylose as starting materials, respectively. They have been expected to display various bioactivities.(2) Several novel N-[(1-ferrocenylethylidene)amino]-N'-β-D-glycopyranosyl-thiourea have been efficiently synthesized via a six-step procedure, utilizing three monosaccharides (D-glucose, D-galactose and D-xylose) as starting materials, respectively. They have been preliminarily determined to display biological activity against certain fungi.(3) A series of novel Schiff base compounds bearing galactosyl have been synthesized. The induction of life matter may efficiently improve their biological activities.